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Drastic effect of ranibizumab on choroidal neovascularization in idiopathic angioid streaks / Efeito dramático do ranibizumabe na neovascularização de coroide em estrias angióides idiopáticas
Yolcu, Umit; Gundogan, Fatih C.; Diner, Oktay.
  • Yolcu, Umit; Siirt Military Hospital. Department of Ophthalmology. Siirt. TR
  • Gundogan, Fatih C.; Siirt Military Hospital. Department of Ophthalmology. Siirt. TR
  • Diner, Oktay; Siirt Military Hospital. Department of Ophthalmology. Siirt. TR
Arq. bras. oftalmol ; 78(4): 257-259, July-Aug. 2015. ilus
Article in English | LILACS | ID: lil-759264
ABSTRACT
ABSTRACTA 28-year-old man presented with bilateral vision loss. His best-corrected visual acuity (BCVA) was 0.3 in the right eye (OD) and 0.6 in the left eye (OS). Fundoscopy and fluorescein angiography showed angioid streaks encircling the optic discs of both eyes (OU). Spectral Domain Optical Coherence Tomography (SD-OCT) showed bilateral macular serous detachment. Systemic and ocular screening tests showed no specific cause for the angioid streaks. The patient had previously received pegaptanib sodium injection on three occasions, photodynamic therapy in OS, and no treatment in OD. Upon intravitreal injection of ranibizumab (twice in OU), subretinal fluid was nearly eliminated in OU. BCVA increased to 0.6 in OD and 0.9 in OS, and remained improved until 6 months after treatment.
RESUMO
RESUMOUm homem de 28 anos apresentou-se com perda de visão bilateral. A melhor acuidade visual corrigida (BCVA) era 0,3 no olho direito (OD) e 0,6 no olho esquerdo (OS). A fundoscopia e a angiofluoresceinografia demonstraram estrias angióides ao redor dos discos ópticos em ambos os olhos (OU). A tomografia de coerência óptica de domínio espectral (SD-OCT) demonstrou descolamento seroso macular bilateral. Testes de triagem sistêmicas e oculares não mostraram causa específica para estrias angióides. O paciente tinha um historia de três tratamentos com injeção de pegaptanibe sódico e terapia fotodinâmica em OS e nenhum tratamento em OD. Após a injeção intravítrea de ranibizumabe (duas vezes em OU), fluido sub-retiniano quase desapareceu em OU. BCVA melhorou para 0,6 em OD e 0,9 em OS e não se alterou até o sexto mês de tratamento.
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Full text: Available Index: LILACS (Americas) Main subject: Choroidal Neovascularization / Angiogenesis Inhibitors / Ranibizumab / Angioid Streaks / Antibodies, Monoclonal Type of study: Etiology study Limits: Adult / Humans / Male Language: English Journal: Arq. bras. oftalmol Journal subject: Ophthalmology Year: 2015 Type: Article Affiliation country: Turkey Institution/Affiliation country: Siirt Military Hospital/TR

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Full text: Available Index: LILACS (Americas) Main subject: Choroidal Neovascularization / Angiogenesis Inhibitors / Ranibizumab / Angioid Streaks / Antibodies, Monoclonal Type of study: Etiology study Limits: Adult / Humans / Male Language: English Journal: Arq. bras. oftalmol Journal subject: Ophthalmology Year: 2015 Type: Article Affiliation country: Turkey Institution/Affiliation country: Siirt Military Hospital/TR