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Early predictive efficacy of core antigen on antiviral outcomes in genotype 1 hepatitis C virus infected patients
Feng, Bo; Yang, Rui-Feng; Zhang, Hai-Ying; Luo, Bi-Fen; Kong, Fan-Yun; Rao, Hui-Ying; Jin, Qian; Cong, Xu; Wei, Lai.
  • Feng, Bo; Peking University. Peking University People's Hospital. Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases. Beijing. CN
  • Yang, Rui-Feng; Peking University. Peking University People's Hospital. Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases. Beijing. CN
  • Zhang, Hai-Ying; Peking University. Peking University People's Hospital. Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases. Beijing. CN
  • Luo, Bi-Fen; Peking University. Peking University People's Hospital. Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases. Beijing. CN
  • Kong, Fan-Yun; Peking University. Peking University People's Hospital. Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases. Beijing. CN
  • Rao, Hui-Ying; Peking University. Peking University People's Hospital. Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases. Beijing. CN
  • Jin, Qian; Peking University. Peking University People's Hospital. Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases. Beijing. CN
  • Cong, Xu; Peking University. Peking University People's Hospital. Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases. Beijing. CN
  • Wei, Lai; Peking University. Peking University People's Hospital. Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases. Beijing. CN
Braz. j. infect. dis ; 19(4): 390-398, July-Aug. 2015. tab, ilus
Article in English | LILACS | ID: lil-759273
ABSTRACT
Response-guided therapy is of limited use in developing countries because hepatitis C virus RNA detection by sensitive molecular methods is time- and labor-consuming and expen- sive. We evaluated early predictive efficacy of serum hepatitis C virus core antigen kinetics on sustained virologic response in patients with genotype 1 hepatitis C virus during pegylated interferon plus ribavirin treatment. For 478 patients recruited, hepatitis C virus RNAs were detected at baseline, and at weeks 4, 12, 24, 48, and 72 using Cobas TaqMan. Architect hepatitis C virus core antigen was performed at baseline, and weeks 4 and 12. Predictive values of hepatitis C virus core antigen on sustained virologic response were compared to hepatitis C virus RNA. In the first 12 weeks after treatment initiation the dynamic patterns of serum hepatitis C virus core antigen and hepatitis C virus RNA levels were similar in sustained virologic response, relapse, and null response patients groups. Although areas under the receiver operating characteristics curves of hepatitis C virus core antigen were lower than those of hepatitis C virus RNA at the same time points, modeling analysis showed that undetectable hepatitis C virus core antigen (rapid virological response based on hepatitis C virus core antigen) had similar positive predictive value on sustained virologic response to hepatitis C virus RNA at week 4 (90.4% vs 93.3%), and hepatitis C virus core antigen decrease greater than 1 log10 IU/mL (early virological response based on hepatitis C virus core antigen) had similar negative predictive value to hepatitis C virus RNA at week 12 (94.1% vs 95.Z%). Analysis on the validation group demonstrated a positive predictivevalue of 97.5% in rapid virological response based on hepatitis C virus core antigen and a negative predictive value of 100% in early virological response based on hepatitis C virus core antigen. In conclusion, hepatitis C virus core antigen is comparable to hepatitis C virus RNA in predicting sustained virologic response of chronic genotype 1 hepatitis C virus infected patients, and can be used to guide anti-hepatitis C virus treatment, especially in resource-limited areas.
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Full text: Available Index: LILACS (Americas) Main subject: Antiviral Agents / Polyethylene Glycols / Ribavirin / Interferon-alpha / Hepacivirus / Hepatitis C Antigens / Hepatitis C, Chronic Type of study: Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2015 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Peking University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Antiviral Agents / Polyethylene Glycols / Ribavirin / Interferon-alpha / Hepacivirus / Hepatitis C Antigens / Hepatitis C, Chronic Type of study: Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2015 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Peking University/CN