Secondary bile acids effects in colon pathology. Experimental mice study
Acta cir. bras
;
30(9): 624-631, Sep. 2015. tab, ilus
Article
in English
| LILACS
| ID: lil-761497
ABSTRACT
ABSTRACTPURPOSE:
To assess whether deoxycholic acid (DOC) and lithocholic acid (LCA) administered in a period of six months in a concentration of 0.25% may have a carcinogenic role in mice colon.METHODS:
The study used C57BL6 female mice divided into four groups. The control group received a balanced diet and the others received diets supplemented with 0.25% DOC, 0.25% LCA and 0.125% DOC+0.125% LCA, respectively. After euthanasia, the lesions found in the resected gastrointestinal tracts were stained with hematoxylin-eosin and examined microscopically.RESULTS:
No gastrointestinal tract changes were observed in the control group, while hyperplastic Peyer's patches in the small intestine, flat adenomas with mild dysplasia and chronic colitis at the level of the colon were found in all three test groups. The colonic lesions prevailed in the proximal colon. The highest number of flat adenoma lesions (8), hyperplasia of Peyer's patches (25) and chronic colitis (2) were found in mice fed with diet and LCA.CONCLUSION:
Precancerous or cancerous pathological lesions could not be identified. Instead, adenomatous colonic injuries occurred in a shorter period of time (six months), compared to the reported data.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Bile Acids and Salts
/
Cholagogues and Choleretics
/
Carcinogens
/
Colon
/
Deoxycholic Acid
/
Lithocholic Acid
Type of study:
Evaluation studies
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2015
Type:
Article
/
Project document
Affiliation country:
Romania
Institution/Affiliation country:
University of Medicine and Pharmacy Tg-Mures/RO
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