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Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease / Determinação da espessura da coróide suas implicações clínicas em pacientes com doença inflamatória intestinal
Onal, Ibrahim Koral; Yuksel, Erdem; Bayrakceken, Kemal; Demir, Muhammed Mustafa; Karaca, Emine Esra; Ibis, Mehmet; Alizadeh, Nasser; Sargin, Zeynep Gok; Hondur, Ahmet Murat; Arhan, Mehmet.
  • Onal, Ibrahim Koral; Gazi University. Medical School. Department of Gastroenterology. Ankara. TR
  • Yuksel, Erdem; Gazi University. Medical School. Department of Gastroenterology. Ankara. TR
  • Bayrakceken, Kemal; Gazi University. Medical School. Department of Gastroenterology. Ankara. TR
  • Demir, Muhammed Mustafa; Gazi University. Medical School. Department of Gastroenterology. Ankara. TR
  • Karaca, Emine Esra; Gazi University. Medical School. Department of Gastroenterology. Ankara. TR
  • Ibis, Mehmet; Gazi University. Medical School. Department of Gastroenterology. Ankara. TR
  • Alizadeh, Nasser; Gazi University. Medical School. Department of Gastroenterology. Ankara. TR
  • Sargin, Zeynep Gok; Gazi University. Medical School. Department of Gastroenterology. Ankara. TR
  • Hondur, Ahmet Murat; Gazi University. Medical School. Department of Gastroenterology. Ankara. TR
  • Arhan, Mehmet; Gazi University. Medical School. Department of Gastroenterology. Ankara. TR
Arq. bras. oftalmol ; 78(5): 278-282, Sep.-Oct. 2015. tab, ilus
Article in English | LILACS | ID: lil-761519
ABSTRACT
ABSTRACTPurpose:Ocular inflammation is a frequent extraintestinal manifestation of inflammatory bowel disease (IBD) and may parallel disease activity. In this study, we evaluated the utility of a choroidal thickness measurement in assessing IBD activity.Methods:A total of 62 eyes of 31 patients with IBD [Crohn's disease (CD), n=10 and ulcerative colitis (UC), n=21] and 104 eyes of 52 healthy blood donors were included in this study. Choroidal thickness was measured using enhanced depth imaging optical coherence tomography. The Crohn's disease activity index (CDAI) and the modified Truelove Witts score were used to assess disease activity in CD and UC, respectively.Results:No significant differences in mean subfoveal, nasal 3000 μm, or temporal 3000 μm choroidal thickness measurements (P>0.05 for all) were observed between IBD patients and healthy controls. Age, smoking, CD site of involvement (ileal and ileocolonic involvement), CDAI, CD activity, and UC endoscopic activity index were all found to be significantly correlated with choroidal thickness by univariate analysis (P<0.05). Smoking (P<0.05) and the CD site of involvement (P<0.01) were the only independent parameters associated with increased choroidal thickness at all measurement locations.Conclusions:Choroidal thickness is not a useful marker of disease activity in patients with IBD but may be an indicator of ileal involvement in patients with CD.
RESUMO
RESUMOObjetivos:Inflamação ocular é uma manifestação extra-intestinal comum de doença inflamatória do intestino (IBD) e pode ser paralela a atividade da doença. Neste estudo, investigamos se a espessura da coroideia pode ser útil para avaliar a atividade da IBD.Método:Um total de 62 olhos de 31 pacientes com IBD [10 com doença de Crohn (CD) e 21 colite ulcerosa (UC)] além de 104 olhos de 52 doadores de sangue saudáveis foram incluídos neste estudo. A espessura da coróide foi medida utilizando-se imagens de tomografia de coerência óptica com profundidade aprimorada. O índice de atividade da doença Crohn (CDAI) e o índice de Truelove Witts modificado foram usados para avaliar atividade da doença em CD e UC, respectivamente.Resultados:Não houve diferença significativa entre os pacientes com IBD e controles saudáveis em termos de medições da espessura da coróide subfoveal média em região 3000 μm nasal e 3000 μm temporal (p>0,05). Com base na análise univariada; idade, tabagismo, local do envolvimento em CD (ileal ou íleo-cecal), CDAI, atividade CD e índice de atividade endoscópica da UC foram significativamente correlacionados com a espessura da coróide (p<0,05). No entanto, fumar (p<0,05) e o local de envolvimento em CD (p<0,01) foram os únicos parâmetros independentes associados com um aumento na espessura da coroideia em todos os pontos de medida.Conclusões:A espessura da coroide não é um marcador útil para refletir a atividade da doença em pacientes com IBD, mas pode ser um indicador de envolvimento ileal em pacientes com CD.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Colitis, Ulcerative / Crohn Disease / Choroiditis / Choroid Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Arq. bras. oftalmol Journal subject: Ophthalmology Year: 2015 Type: Article Affiliation country: Turkey Institution/Affiliation country: Gazi University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Colitis, Ulcerative / Crohn Disease / Choroiditis / Choroid Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Arq. bras. oftalmol Journal subject: Ophthalmology Year: 2015 Type: Article Affiliation country: Turkey Institution/Affiliation country: Gazi University/TR