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Long-term correlation of the electrocorticogram as a bioindicator of brain exposure to ionizing radiation
Aguiar, L.A.A.; Silva, I.M.S.; Fernandes, T.S.; Nogueira, R.A..
  • Aguiar, L.A.A.; Universidade Federal Rural de Pernambuco. Laboratório de Biofísica Teórico-Experimental e Computacional. Departamento de Morfologia e Fisiologia Animal. PE. BR
  • Silva, I.M.S.; Universidade Federal Rural de Pernambuco. Laboratório de Biofísica Teórico-Experimental e Computacional. Departamento de Morfologia e Fisiologia Animal. PE. BR
  • Fernandes, T.S.; Universidade Federal Rural de Pernambuco. Laboratório de Biofísica Teórico-Experimental e Computacional. Departamento de Morfologia e Fisiologia Animal. PE. BR
  • Nogueira, R.A.; Universidade Federal Rural de Pernambuco. Laboratório de Biofísica Teórico-Experimental e Computacional. Departamento de Morfologia e Fisiologia Animal. PE. BR
Braz. j. med. biol. res ; 48(10): 915-922, Oct. 2015. ilus
Article in English | LILACS | ID: lil-761596
ABSTRACT
Understanding the effects of radiation and its possible influence on the nervous system are of great clinical interest. However, there have been few electrophysiological studies on brain activity after exposure to ionizing radiation (IR). A new methodological approach regarding the assessment of the possible effects of IR on brain activity is the use of linear and nonlinear mathematical methods in the analysis of complex time series, such as brain oscillations measured using the electrocorticogram (ECoG). The objective of this study was to use linear and nonlinear mathematical methods as biomarkers of gamma radiation regarding cortical electrical activity. Adult Wistar rats were divided into 3 groups 1 control and 2 irradiated groups, evaluated at 24 h (IR24) and 90 days (IR90) after exposure to 18 Gy of gamma radiation from a cobalt-60 radiotherapy source. The ECoG was analyzed using power spectrum methods for the calculation of the power of delta, theta, alpha and beta rhythms and by means of the α-exponent of the detrended fluctuation analysis (DFA). Using both mathematical methods it was possible to identify changes in the ECoG, and to identify significant changes in the pattern of the recording at 24 h after irradiation. Some of these changes were persistent at 90 days after exposure to IR. In particular, the theta wave using the two methods showed higher sensitivity than other waves, suggesting that it is a possible biomarker of exposure to IR.
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Full text: Available Index: LILACS (Americas) Main subject: Radiation Injuries / Radiation, Ionizing / Cerebral Cortex / Electrocorticography / Gamma Rays Type of study: Prognostic study Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal Rural de Pernambuco/BR

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Full text: Available Index: LILACS (Americas) Main subject: Radiation Injuries / Radiation, Ionizing / Cerebral Cortex / Electrocorticography / Gamma Rays Type of study: Prognostic study Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal Rural de Pernambuco/BR