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Evolución alejada en portadoras asintomáticos HBsAg(PA-HBsAg) en un área de baja prevalencia de hepatocarcinoma
Acta gastroenterol. latinoam ; 19(1): 21-30, jan.-mar. 1989. tab
Article in Spanish | LILACS | ID: lil-76189
RESUMO
Data provided by 51 voluntaru blood donnors identified as asymptomatic HBsAg carriers five to ten years (x = 7.5 years) before their inclusion in the study are analysed towards their long-term evolution. HBsAg clearance was estimated 2.5% yearly and 83.9% of those remaining positive showed the classical non-replicative serological pattern,; another 12.9% were negative for both HBeAg - Anti HBe (serovonversion window?), one of them presenting raised ASATALAT levels and enhanced histological activity (lobular chronic hepatitis). Neither alpha-fetoprotein seric levels (RIA) nor liver ultrasonography demonstrated hepato cellular carcinoma suspicion signs in 35 HBsAg positive cases to this methods; ASAT-ALAT levels raised over two fold the normal superior limit ion only 11.4%, and neither agressive chronic liver disease nor hepatocyte dissplasia was showed in 17 biopsed cases (70.6% normal; 23.6% chronic reactive or chronic persistent hepatitis; 5.8% chronic liobular hepatitis). One out of five patients biopsed with a seven years interval showed histologic worsening
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Index: LILACS (Americas) Main subject: Hepatitis B virus / Carcinoma, Hepatocellular / Hepatitis B / Hepatitis B Surface Antigens / Liver Neoplasms Type of study: Prevalence study / Risk factors / Screening study Limits: Humans Language: Spanish Journal: Acta gastroenterol. latinoam Journal subject: Gastroenterology Year: 1989 Type: Article

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Index: LILACS (Americas) Main subject: Hepatitis B virus / Carcinoma, Hepatocellular / Hepatitis B / Hepatitis B Surface Antigens / Liver Neoplasms Type of study: Prevalence study / Risk factors / Screening study Limits: Humans Language: Spanish Journal: Acta gastroenterol. latinoam Journal subject: Gastroenterology Year: 1989 Type: Article