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Prevalência da lesão HPV induzida em canal anal de mulheres com neoplasia intraepitelial cervical 2 e 3: um estudo de corte transversal / Prevalence of HPV-induced lesions in the anal canal among women with cervical intraepithelial neoplasia 2 and 3: cross-sectional study
heráclio, Sandra de andrade; araujo, Thaís antunes de; souza, Alex sandro rolland; cahen, Kristiane; lima junior, Sergio ferreira; de souza, Paulo roberto eleutério; amorim, Melania maria ramos.
  • heráclio, Sandra de andrade; Instituto de Medicina Integral Prof. Fernando Figueira. Recife. BR
  • araujo, Thaís antunes de; Instituto de Medicina Integral Prof. Fernando Figueira. Recife. BR
  • souza, Alex sandro rolland; Instituto de Medicina Integral Prof. Fernando Figueira. Recife. BR
  • cahen, Kristiane; Instituto de Medicina Integral Prof. Fernando Figueira. Recife. BR
  • lima junior, Sergio ferreira; Instituto de Medicina Integral Prof. Fernando Figueira. Recife. BR
  • de souza, Paulo roberto eleutério; Instituto de Medicina Integral Prof. Fernando Figueira. Recife. BR
  • amorim, Melania maria ramos; Instituto de Medicina Integral Prof. Fernando Figueira. Recife. BR
Rev. bras. ginecol. obstet ; 37(10): 480-485, out. 2015. tab
Article in Portuguese | LILACS | ID: lil-762027
RESUMO

OBJETIVO:

Determinar a prevalência da lesão anal induzida por HPV em mulheres com neoplasia intraepitelial cervical grau 2/3 (NIC2/3).

MÉTODOS:

Estudo transversal, realizado no período de dezembro de 2008 a junho de 2009, no Estado de Pernambuco, nordeste do Brasil. Foram incluídas no estudo apenas mulheres com diagnóstico de NIC2/3 confirmado por biópsia e excluídas aquelas que não realizaram exame na primeira visita. As amostras para identificação do DNA de HPV anal por PCR e citologia anal foram coletadas com escovinha endocervical. A biópsia anal foi realizada nos casos de citologia anal anormal ou alterações maiores na anuscopia de alta resolução (AAR).

RESULTADOS:

Das AARs, 32,1% (n=37/115) foram normais e 63,5% (n=73/115) exibiram epitélio acetobranco. Vinte e dois por cento das citologias anais (n=26/115) foram anormais. Dentre elas, 12,2% (14/26) corresponderam à lesão intraepitelial anal de baixo grau e 3,4% (n=4/26), a lesão intraepitelial anal de alto grau. Foram realizadas 22 biópsias, das quais 13,7% (n=3/22) tiveram diagnóstico de neoplasia intraepitelial anal (NIA2) e 9% (n=2/22), NIA 3. Identificou-se 72,1% (n=83/115) de DNA do HPV nas amostras.

CONCLUSÃO:

Mulheres com NIC2/3 apresentam elevada prevalência de infecção por HPV e lesão HPV induzida em canal anal.
ABSTRACT

PURPOSE:

To determine the prevalence of HPV-induced lesions in the anal canal of women with cervical intraepithelial neoplasia (CIN) grade 2/3.

METHODS:

A cross-sectional study was carried out from December 2008 to June 2009, in Pernambuco, northeastern Brazil. Only women with grade 2/3 CIN were included, and those who could not undergo anoscopy during their first visit were excluded. A cyttobrush was used for sample collection in order to identify HPV DNA through PCR and anal cytology. An anal biopsy was obtained in cases of abnormal anal cytology or major alterations in high resolution anoscopy (HRA).

RESULTS:

Thirty-two percent (n=37/115) of HRA were normal and 63.5% (n=73/115) showed acetowhite epithelium. Twenty-two percent (n=26/115) of anal cytologies were abnormal. Among the latter, 12.2% (n=14/26) were low-grade anal intraepithelial lesions and 3.4% (n=4/26) were high-grade anal intraepithelial lesions. Twenty-two anal biopsies were performed, 13.7% of which (n=3/22) were grade 2 anal intraepithelial neoplasia (AIN2) and 9% (n=2/22) were grade 3 AIN. Th HPV DNA was identified in 72.1% of cases (n=83/115).

CONCLUSION:

Women with CIN grade 2/3 showed a high prevalence of anal HPV infection and HPV-induced lesions.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Anus Diseases / Uterine Cervical Dysplasia / Uterine Cervical Neoplasms / Papillomavirus Infections Type of study: Observational study / Prevalence study / Screening study Limits: Adolescent / Adult / Female / Humans Country/Region as subject: South America / Brazil Language: Portuguese Journal: Rev. bras. ginecol. obstet Journal subject: Gynecology / Obstetrics Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto de Medicina Integral Prof. Fernando Figueira/BR

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Full text: Available Index: LILACS (Americas) Main subject: Anus Diseases / Uterine Cervical Dysplasia / Uterine Cervical Neoplasms / Papillomavirus Infections Type of study: Observational study / Prevalence study / Screening study Limits: Adolescent / Adult / Female / Humans Country/Region as subject: South America / Brazil Language: Portuguese Journal: Rev. bras. ginecol. obstet Journal subject: Gynecology / Obstetrics Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto de Medicina Integral Prof. Fernando Figueira/BR