Your browser doesn't support javascript.
loading
Phyllanthus emblica l. branch extract ameliorates testicular damage in valproic acid-induced rats / El extracto de la rama de Phyllanthus emblica l. disminuye el daño testicular inducido por ácido valproico en ratas
Iamsaard, Sitthichai; Arun, Supatcharee; Burawat, Jaturon; Sukhorum, Wannisa; Boonruangsri, Porntip; Namking, Malivalaya; Uabundit, Nongnut; Nualkaew, Somsak; Sripanidkulchai, Bungorn.
  • Iamsaard, Sitthichai; Khon Kaen University. Faculty of Medicine. Department of Anatomy. Khon Kaen. TH
  • Arun, Supatcharee; Khon Kaen University. Faculty of Medicine. Department of Anatomy. Khon Kaen. TH
  • Burawat, Jaturon; Khon Kaen University. Faculty of Medicine. Department of Anatomy. Khon Kaen. TH
  • Sukhorum, Wannisa; Khon Kaen University. Faculty of Medicine. Department of Anatomy. Khon Kaen. TH
  • Boonruangsri, Porntip; Khon Kaen University. Faculty of Medicine. Department of Anatomy. Khon Kaen. TH
  • Namking, Malivalaya; Khon Kaen University. Faculty of Medicine. Department of Anatomy. Khon Kaen. TH
  • Uabundit, Nongnut; Khon Kaen University. Faculty of Medicine. Department of Anatomy. Khon Kaen. TH
  • Nualkaew, Somsak; Mahasarakham University. Faculty of Pharmacy. Department of Pharmaceutical Sciences. Mahasarakham. TH
  • Sripanidkulchai, Bungorn; Khon Kaen University. Faculty of Pharmaceutical Sciences. Center for Research and Development of Herbal Health Product. Khon Kaen. TH
Int. j. morphol ; 33(3): 1016-1022, Sept. 2015. ilus
Article in English | LILACS | ID: lil-762579
ABSTRACT
Valproic acid (VPA), widely used in treating epileptic patients, can damage reproductive parameters causing male infertility. This study aimed to investigate protective effect of Phyllanthus emblica L. branch (PE) extract on rat testicular damage induced with VPA. Male rats were divided into 6 groups (control, VPA, 250 mg/kgBW PE only, and 50, 100, 250 mg/kgBW PE+VPA, respectively). Animals were pretreated with PE for 23 days and co-administered with VPA for 10 days before all reproductive parameters were determined. The results showed all doses of PE significantly protected the decrease testicular weight and testosterone level in VPA rats. PE significantly improved the decrease sperm concentration in VPA treated rats. Moreover, testicular histology of PE+VPA groups showed declining of testicular histopathologies as compared to VPA group. Therefore, it seems that PE branch extract can prevent testicular damages including male reproductive parameters in rats induced with VPA.
RESUMEN
El ácido valproico (AVP) es utilizado frecuentemente en el tratamiento de pacientes epilépticos y puede dañar los parámetros reproductivos que causan la infertilidad masculina. Este estudio tuvo como objetivo investigar el efecto protector de la rama Phyllanthus emblica L. (PE) sobre el daño testicular de ratas inducidas con AVP. Ratas machos fueron divididas en 6 grupos (control, AVP, PE 250 mg/kg peso corporal, APV+ PE 50, 100, 250 mg/kg peso corporal, respectivamente). Los animales fueron pretratados con PE durante 23 días y se administró AVP durante 10 días antes de medir todos los parámetros reproductivos. Los resultados mostraron que todas las dosis de PE protegen significativamente el peso y los niveles reducidos de testosterona testicular en ratas con AVP. El extracto de PE mejoró significativamente la concentración de espermatozoides en ratas tratadas con AVP. Por otra parte, la histología testicular de los grupos PE+AVP mostró disminución de la histopatología testicular en comparación con el grupo tratado sólo con AVP. Por lo tanto, parece que el extracto de la rama PE puede prevenir daños testiculares incluyendo los parámetros reproductores masculinos en ratas inducidas con AVP.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Testis / Plant Extracts / Valproic Acid / Phyllanthus emblica Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2015 Type: Article / Project document Affiliation country: Thailand Institution/Affiliation country: Khon Kaen University/TH / Mahasarakham University/TH

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Testis / Plant Extracts / Valproic Acid / Phyllanthus emblica Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2015 Type: Article / Project document Affiliation country: Thailand Institution/Affiliation country: Khon Kaen University/TH / Mahasarakham University/TH