Síndrome hemofagocítico adquirido: reporte de casos de cuatro pacientes adultos tratados con protocolo HLH 94-04 y revisión de la literatura / Acquired hemophagocytic syndrome treated with HLH 94-04 chemotherapy protocol: Report of four cases
Rev. méd. Chile
;
143(9): 1172-1178, set. 2015. tab
Article
in Spanish
| LILACS
| ID: lil-762688
ABSTRACT
Hemophagocytic syndrome is a severe condition of excessive immune activation that has a high mortality in the absence of treatment. The syndrome is classified as primary if associated with congenital or hereditary problems, or secondary/acquired if associated with infectious, autoimmune or oncology diseases. We report four adult cases of the syndrome, one with viral, two with autoimmune and one with idiopathic causes who were successfully treated with HLH 94-04 chemotherapy protocol. Our experience shows that a high index of suspicion, early diagnosis and an opportune therapy are essential in the treatment of this disease.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Dexamethasone
/
Methotrexate
/
Cyclosporine
/
Lymphohistiocytosis, Hemophagocytic
/
Etoposide
/
Immunosuppressive Agents
Type of study:
Diagnostic study
/
Practice guideline
/
Screening study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2015
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Pontificia Universidad Catolica de Chile/CL
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