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Biological significance of miR-126 expression in atrial fibrillation and heart failure
Wei, X.J.; Han, M.; Yang, F.Y.; Wei, G.C.; Liang, Z.G.; Yao, H.; Ji, C.W.; Xie, R.S.; Gong, C.L.; Tian, Y..
  • Wei, X.J.; The People’s Hospital of Laiwu City. Intensive Care Unit. Laiwu City. CN
  • Han, M.; The People’s Hospital of Laiwu City. Intensive Care Unit. Laiwu City. CN
  • Yang, F.Y.; The People’s Hospital of Laiwu City. Intensive Care Unit. Laiwu City. CN
  • Wei, G.C.; The People’s Hospital of Laiwu City. Intensive Care Unit. Laiwu City. CN
  • Liang, Z.G.; The People’s Hospital of Laiwu City. Intensive Care Unit. Laiwu City. CN
  • Yao, H.; The People’s Hospital of Laiwu City. Intensive Care Unit. Laiwu City. CN
  • Ji, C.W.; The People’s Hospital of Laiwu City. Intensive Care Unit. Laiwu City. CN
  • Xie, R.S.; The People’s Hospital of Laiwu City. Intensive Care Unit. Laiwu City. CN
  • Gong, C.L.; The People’s Hospital of Laiwu City. Intensive Care Unit. Laiwu City. CN
  • Tian, Y.; The People’s Hospital of Laiwu City. Intensive Care Unit. Laiwu City. CN
Braz. j. med. biol. res ; 48(11): 983-989, Nov. 2015. tab
Article in English | LILACS | ID: lil-762906
ABSTRACT
We investigated the biological significance of microRNA-126 (miR-126) expression in patients with atrial fibrillation (AF) and/or heart failure (HF) to examine the possible mechanism of miR-126-dependent AF and development of HF. A total of 103 patients were divided into three groups AF group (18 men and 17 women, mean age 65.62±12.72 years), HF group (17 men and 15 women, mean age 63.95±19.71 years), and HF-AF group (20 men and 16 women, mean age 66.56±14.37 years). Quantitative real-time PCR was used to measure relative miR-126 expression as calculated by the 2−ΔΔCt method. miR-126 was frequently downregulated in the 3 patient groups compared with controls. This reduction was significantly lower in permanent and persistent AF patients than in those with paroxysmal AF (P<0.05, t-test). Moreover, miR-126 expression was markedly lower in the HF-AF group compared with the AF and HF groups. The 3 patient groups had higher N-terminal prohormone brain natriuretic peptide (NT-proBNP) levels, lower left ventricular ejection fraction (LVEF), larger left atrial diameter, and higher cardiothoracic ratio compared with controls. There were significant differences in NT-proBNP levels and LVEF among the AF, HF, and HF-AF groups. Pearson correlation analysis showed that relative miR-126 expression was positively associated with LVEF, logarithm of NT-proBNP, left atrial diameter, cardiothoracic ratio, and age in HF-AF patients. Multiple linear regression analysis showed that miR-126 expression was positively correlated with LVEF, but negatively correlated with the logarithm of NT-pro BNP and the cardiothoracic ratio (all P<0.05). Serum miR-126 levels could serve as a potential candidate biomarker for evaluating the severity of AF and HF. However, to confirm these results, future studies with a larger and diverse patient population are necessary.
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Full text: Available Index: LILACS (Americas) Main subject: Atrial Fibrillation / MicroRNAs / Heart Failure Type of study: Diagnostic study / Prognostic study Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2015 Type: Article Affiliation country: China Institution/Affiliation country: The People&#8217;s Hospital of Laiwu City/CN

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Full text: Available Index: LILACS (Americas) Main subject: Atrial Fibrillation / MicroRNAs / Heart Failure Type of study: Diagnostic study / Prognostic study Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2015 Type: Article Affiliation country: China Institution/Affiliation country: The People&#8217;s Hospital of Laiwu City/CN