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Whole-genome sequencing of a Plasmodium vivax isolate from the China-Myanmar border area
Shen, Hai-Mo; Chen, Shen-Bo; Wang, Yue; Chen, Jun-Hu.
  • Shen, Hai-Mo; National Institute of Parasitic Diseases. Chinese Center for Disease Control and Prevention. Shanghai. CN
  • Chen, Shen-Bo; National Institute of Parasitic Diseases. Chinese Center for Disease Control and Prevention. Shanghai. CN
  • Wang, Yue; National Institute of Parasitic Diseases. Chinese Center for Disease Control and Prevention. Shanghai. CN
  • Chen, Jun-Hu; National Institute of Parasitic Diseases. Chinese Center for Disease Control and Prevention. Shanghai. CN
Mem. Inst. Oswaldo Cruz ; 110(6): 814-816, Sept. 2015. tab, graf
Article in English | LILACS | ID: lil-763088
Responsible library: BR1.1
ABSTRACT
Currently, there is a trend of an increasing number of Plasmodium vivaxmalaria cases in China that are imported across its Southeast Asia border, especially in the China-Myanmar border area (CMB). To date, little is known about the genetic diversity of P. vivaxin this region. In this paper, we report the first genome sequencing of a P. vivaxisolate (CMB-1) from a vivax malaria patient in CMB. The sequencing data were aligned onto 96.43% of the P. vivaxSalvador I reference strain (Sal I) genome with 7.84-fold coverage as well as onto 98.32% of 14 Sal I chromosomes. Using the de novoassembly approach, we generated 8,541 scaffolds and assembled a total of 27.1 Mb of sequence into CMB-1 scaffolds. Furthermore, we identified all 295 known virgenes, which is the largest subtelomeric multigene family in malaria parasites. These results provide an important foundation for further research onP. vivaxpopulation genetics.
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Full text: Available Index: LILACS (Americas) Main subject: Plasmodium vivax / DNA, Protozoan / Sequence Analysis, DNA / Genome, Protozoan Country/Region as subject: Asia Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2015 Type: Article / Project document Affiliation country: China Institution/Affiliation country: National Institute of Parasitic Diseases/CN

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Full text: Available Index: LILACS (Americas) Main subject: Plasmodium vivax / DNA, Protozoan / Sequence Analysis, DNA / Genome, Protozoan Country/Region as subject: Asia Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2015 Type: Article / Project document Affiliation country: China Institution/Affiliation country: National Institute of Parasitic Diseases/CN