Your browser doesn't support javascript.
loading
Toxocara canis and the allergic process
Zaia, Mauricio Grecco; Oliveira, Sandra Regina Pereira de; Castro, Cynthia Aparecida de; Soares, Edson Garcia; Afonso, Ana; Monnazzi, Luis Gustavo S; Peitl Filho, Oscar; Faccioli, Lúcia Helena; Anibal, Fernanda de Freitas.
  • Zaia, Mauricio Grecco; Universidade Federal de São Carlos. Centro de Ciências Biológicas e da Saúde. Departamento de Morfologia e Patologia. BR
  • Oliveira, Sandra Regina Pereira de; Universidade Federal de São Carlos. Centro de Ciências Biológicas e da Saúde. Departamento de Morfologia e Patologia. BR
  • Castro, Cynthia Aparecida de; Universidade Federal de São Carlos. Centro de Ciências Biológicas e da Saúde. Departamento de Morfologia e Patologia. BR
  • Soares, Edson Garcia; Universidade Federal de São Carlos. Centro de Ciências Biológicas e da Saúde. Departamento de Morfologia e Patologia. BR
  • Afonso, Ana; Universidade Federal de São Carlos. Centro de Ciências Biológicas e da Saúde. Departamento de Morfologia e Patologia. BR
  • Monnazzi, Luis Gustavo S; Universidade Federal de São Carlos. Centro de Ciências Biológicas e da Saúde. Departamento de Morfologia e Patologia. BR
  • Peitl Filho, Oscar; Universidade Federal de São Carlos. Centro de Ciências Biológicas e da Saúde. Departamento de Morfologia e Patologia. BR
  • Faccioli, Lúcia Helena; Universidade Federal de São Carlos. Centro de Ciências Biológicas e da Saúde. Departamento de Morfologia e Patologia. BR
  • Anibal, Fernanda de Freitas; Universidade Federal de São Carlos. Centro de Ciências Biológicas e da Saúde. Departamento de Morfologia e Patologia. BR
Mem. Inst. Oswaldo Cruz ; 110(6): 726-731, Sept. 2015. tab, graf
Article in English | LILACS | ID: lil-763099
Responsible library: BR1.1
ABSTRACT
The protective effect of infectious agents against allergic reactions has been thoroughly investigated. Current studies have demonstrated the ability of some helminths to modulate the immune response of infected hosts. The objective of the present study was to investigate the relationship between Toxocara canis infection and the development of an allergic response in mice immunised with ovalbumin (OVA). We determined the total and differential blood and bronchoalveolar lavage fluid cells using BALB/c mice as a model. To this end, the levels of interleukin (IL)-4, IL-5 and IL-10 and anti-OVA-IgE were measured using an ELISA. The inflammatory process in the lungs was observed using histology slides stained with haematoxylin and eosin. The results showed an increase in the total number of leukocytes and eosinophils in the blood of infected and immunised animals at 18 days after infection. We observed a slight lymphocytic inflammatory infiltrate in the portal space in all infected mice. Anti-OVA-IgE levels were detected in smaller proportions in the plasma of immunised and infected mice compared with mice that were only infected. Therefore, we concluded that T. canis potentiates inflammation in the lungs in response to OVA, although anti-OVA-IgE levels suggest a potential reduction of the inflammatory process through this mechanism.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Bronchoalveolar Lavage Fluid / Toxocariasis / Toxocara canis / Hypersensitivity / Lung Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de São Carlos/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Bronchoalveolar Lavage Fluid / Toxocariasis / Toxocara canis / Hypersensitivity / Lung Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de São Carlos/BR