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Effects of intraoperative diltiazem infusion on flow changes in arterial and venous grafts in coronary artery bypass graft surgery / Efeitos da infusão intraoperatória de diltiazem sobre as mudanças do fluxo em enxertos arteriais e venosos em cirurgia de revascularização do miocárdio
Erdem, Ozan; Memetoğlu, Mehmet Erdem; Tekin, Ali İhsan; Arslan, Ümit; Akkaya, Özgür; Kutlu, Rasim; Gölbaşı, İlhan.
  • Erdem, Ozan; Akdeniz University. School of Medicine. Antalya. TR
  • Memetoğlu, Mehmet Erdem; Akdeniz University. School of Medicine. Antalya. TR
  • Tekin, Ali İhsan; Akdeniz University. School of Medicine. Antalya. TR
  • Arslan, Ümit; Akdeniz University. School of Medicine. Antalya. TR
  • Akkaya, Özgür; Akdeniz University. School of Medicine. Antalya. TR
  • Kutlu, Rasim; Akdeniz University. School of Medicine. Antalya. TR
  • Gölbaşı, İlhan; Akdeniz University. School of Medicine. Antalya. TR
Rev. bras. cir. cardiovasc ; 30(4): 459-465, July-Aug. 2015. tab
Article in English | LILACS | ID: lil-763153
ABSTRACT
Abstract

Objective:

This study aimed to show the effects of intra-operative diltiazem infusion on flow in arterial and venous grafts in coronary artery bypass graft surgery.

Methods:

Hundred fourty patients with a total of 361 grafts [205 (57%) arterial and 156 (43%) venous] underwent isolated coronary surgery. All the grafts were measured by intraoperative transit time flow meter intra-operatively. Group A (n=70) consisted of patients who received diltiazem infusion (dose of 2.5 microgram/kg/min), and Group B (n=70) didn't receive diltiazem infusion.

Results:

Mean graft flow values of left internal mammary artery were 53 ml/min in Group A and 40 ml/min in Group B (P<0.001). Pulsatility index (PI) values of left internal mammary artery for Group A and Group B were 2.6 and 3.0 respectively (P<0.001). No statistically significant difference was found between venous graft parameters.

Conclusion:

We recommend an effect of diltiazem infusion in increasing graft flows in coronary artery bypass graft operations.
RESUMO
Resumo

Objetivo:

Este estudo teve como objetivo mostrar os efeitos da infusão de diltiazem intraoperatória no fluxo arterial e enxertos venosos em cirurgia de revascularização do miocárdio.

Métodos:

Cento e quarenta pacientes com um total de 361 enxertos [205 (57%) arteriais e 156 (43%) venosos] passaram por uma cirurgia coronária isolada. Todos os enxertos foram medidos pelo medidor de fluxo de tempo de trânsito intraoperatório. Grupo A (n=70), formado por pacientes que receberam infusão de diltiazem (dose de 2,5 micrograma/kg/min), e Grupo B (n=70), por aqueles que não receberam infusão de diltiazem.

Resultados:

Os valores médios de fluxo de enxerto de artéria mamária interna esquerda foram 53 ml/min no grupo A e 40 ml/min no Grupo B (P<0,001). Valores do índice de pulsatilidade da artéria mamária interna esquerda para o Grupo A e do Grupo B foram de 2,6 e 3,0, respectivamente (P<0,001). Não houve diferença estatisticamente significativa entre os parâmetros do enxerto venoso.

Conclusão:

Sugerimos um efeito da infusão de diltiazem em aumentar os fluxos de enxerto em operações de bypass de artéria coronária.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Infusions, Intra-Arterial / Diltiazem / Myocardial Reperfusion / Coronary Artery Bypass / Coronary Circulation / Vascular Grafting / Intraoperative Care / Antihypertensive Agents Type of study: Controlled clinical trial / Prognostic study Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Rev. bras. cir. cardiovasc Journal subject: Cardiology / General Surgery Year: 2015 Type: Article Affiliation country: Turkey Institution/Affiliation country: Akdeniz University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Infusions, Intra-Arterial / Diltiazem / Myocardial Reperfusion / Coronary Artery Bypass / Coronary Circulation / Vascular Grafting / Intraoperative Care / Antihypertensive Agents Type of study: Controlled clinical trial / Prognostic study Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Rev. bras. cir. cardiovasc Journal subject: Cardiology / General Surgery Year: 2015 Type: Article Affiliation country: Turkey Institution/Affiliation country: Akdeniz University/TR