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Hígado graso agudo del embarazo y síndrome HELLP: aspectos diagnósticos y terapéuticos / Acute fatty liver of pregnancy and HELLP syndrome: diagnostic and therapeutic aspects
Muñoz T., Cristián.
  • Muñoz T., Cristián; Hospital del Salvador. Unidad de Trasplante Hepático. Santiago. CL
Gastroenterol. latinoam ; 24(supl.1): S123-S126, 2013. tab
Article in Spanish | LILACS | ID: lil-763740
ABSTRACT
HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count) and acute fatty liver of pregnancy (AFLP), cause liver dysfunction in the third trimester of pregnancy and determine risk of maternal and fetal mortality. Many maternal complications can occur, including acute renal failure and coagulopathy. Early diagnosis, prompt delivery and adequate supportive care are the key to a good outcome in most of the patients. In some cases, despite an appropriate conventional management, the disease may progress to multiple organ dysfunction, progressive liver insufficiency or severe hepatic complications (subcapsular hematoma, liver rupture), requiring adjunctive medical therapy, such as plasma exchange, surgery or liver transplantation.
RESUMEN
El síndrome HELLP (hemolysis, elevated liver enzymes, and low platelet count) y el hígado graso agudo del embarazo (acute fatty liver of pregnancy -AFLP), son causa de disfunción hepática en el tercer trimestre del embarazo y condicionan riesgo de mortalidad materna fetal. Se pueden presentar diversas complicaciones como insuficiencia renal aguda y coagulopatía, entre otras. El diagnóstico oportuno, la interrupción del embarazo y un manejo de sostén adecuado permiten sacar adelante a la mayoría de las pacientes. En algunos casos, a pesar de un manejo convencional adecuado, la enfermedad puede evolucionar con disfunción multiorgánica, insuficiencia hepática progresiva o complicaciones hepáticas graves (hematoma subcapsular, rotura hepática), requiriendo de terapia médica adyuvante, como la plasmaféresis, cirugía o incluso trasplante hepático.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Pregnancy Complications / HELLP Syndrome / Fatty Liver Type of study: Diagnostic study / Screening study Limits: Female / Humans / Pregnancy Language: Spanish Journal: Gastroenterol. latinoam Journal subject: Gastroenterology Year: 2013 Type: Article Affiliation country: Chile Institution/Affiliation country: Hospital del Salvador/CL

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Full text: Available Index: LILACS (Americas) Main subject: Pregnancy Complications / HELLP Syndrome / Fatty Liver Type of study: Diagnostic study / Screening study Limits: Female / Humans / Pregnancy Language: Spanish Journal: Gastroenterol. latinoam Journal subject: Gastroenterology Year: 2013 Type: Article Affiliation country: Chile Institution/Affiliation country: Hospital del Salvador/CL