Interval training based on ventilatory anaerobic threshold increases cardiac vagal modulation and decreases high-sensitivity c-reative protein: randomized clinical trial in coronary artery disease
Braz. j. phys. ther. (Impr.)
;
19(6): 441-450, Nov.-Dec. 2015. tab, graf
Article
in English
| LILACS
| ID: lil-767067
ABSTRACT
Background:
Autonomic dysfunction and inflammatory activity are involved in the development and progression of coronary artery disease (CAD), and exercise training has been shown to confer a cardiovascular benefit.Objective:
To evaluate the effects that interval training (IT) based on ventilatory anaerobic threshold (VAT) has on heart rate variability (HRV) and high-sensitivity C-reactive protein (hs-CRP) levels, as well as the relationship between both levels, in patients with CAD and/or cardiovascular risk factors (RF).Method:
Forty-two men (aged 57.88±6.20 years) were divided into two training groups, CAD-T (n= 12) and RF-T (n= 10), and two control groups, CAD-C (n= 10) and RF-C (n=10). Heart rate and RR intervals in the supine position, cardiopulmonary exercise tests, and hs-CRP levels were measured before and after IT. HRV was analyzed by spectral and symbolic analysis. The CAD-T and RF-T underwent a 16-week IT program of three weekly sessions at training intensities based on the VAT.Results:
In the RF-T, cardiac sympathetic modulation index and hs-CRP decreased (p<0.02), while cardiac parasympathetic modulation index increased (p<0.02). In the CAD-T, cardiac parasympathetic modulation index increased, while hs-CRP, systolic, and diastolic blood pressures decreased (p<0.02). Both control groups showed increase in hs-CRP parameters (p<0.02). There was a strong and significant association between parasympathetic and sympathetic modulations with hs-CRP.Conclusion:
The IT program based on the VAT promoted a decrease in hs-CRP associated with improvement in cardiac autonomic modulation.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Vagus Nerve
/
Blood Pressure
/
Coronary Artery Disease
/
C-Reactive Protein
/
Anaerobic Threshold
/
Cardiovascular Diseases
/
Heart Rate
Type of study:
Controlled clinical trial
/
Diagnostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Braz. j. phys. ther. (Impr.)
Journal subject:
MEDICINA FISICA E REABILITACAO
Year:
2015
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de São Carlos/BR
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