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Peripapillary retinal nerve fiber layer and choroidal thickness in cirrhosis patients / Espessura da camada de fibras nervosas peripapilares da retina e coroide em pacientes com cirrose
Akdemir, M. Orcun; Ayar, Orhan; Yazgan, Serpil; Ilikhan, Sevil Uygun; Celik, Erkan; Ugurbas, Suat H; Ustundag, Yucel.
  • Akdemir, M. Orcun; Bülent Ecevit University. School of Medicine. Zonguldak. TR
  • Ayar, Orhan; Bülent Ecevit University. School of Medicine. Zonguldak. TR
  • Yazgan, Serpil; Bülent Ecevit University. School of Medicine. Zonguldak. TR
  • Ilikhan, Sevil Uygun; Bülent Ecevit University. School of Medicine. Zonguldak. TR
  • Celik, Erkan; Bülent Ecevit University. School of Medicine. Zonguldak. TR
  • Ugurbas, Suat H; Bülent Ecevit University. School of Medicine. Zonguldak. TR
  • Ustundag, Yucel; Bülent Ecevit University. School of Medicine. Zonguldak. TR
Rev. bras. oftalmol ; 74(6): 345-349, nov.-dez. 2015. tab, graf
Article in English | LILACS | ID: lil-767086
ABSTRACT
ABSTRACT

Purpose:

To evaluate the effect of cirrhosis on peripapillary retinal nerve fiber layer and choroidal thickness with enhanced depth imaging optical coherence tomography.

Methods:

This cross sectional, single center study was undertaken at Bulent Ecevit University Ophthalmology department with the participation of internal medicine, Gastroenterology department. Patients who were treated with the diagnosis of cirrhosis (n=75) were examined in the ophthalmology clinic. Age and sex matched patients (n=50) who were healthy and met the inclusion, exclusion criteria were included in the study. Complete ophthalmological examination included visual acuity with Snellen chart, intraocular pressure measurement with applanation tonometry, biomicroscopy of anterior and posterior segments, gonioscopy, axial length measurement, visual field examination, peripapillary retinal nerve fiber layer, central macular and subfoveal choroidal thickness measurements.

Results:

The difference between intraocular pressure values was not statistically significant between cirrhosis and control group (p=0.843). However, mean peripapillary retinal nerve fiber layer thickness was significantly thinner in cirrhosis group in all regions (p<0.001) and subfoveal choroidal thickness was significantly thinner in cirrhosis group also (p<0.001). Moreover, central macular thickness of cirrhosis group was significantly thicker than the control group (p=0.001).

Conclusion:

Peripapillary retinal nerve fiber layer and subfoveal choroidal thickness was significantly thinner in cirrhosis patients.
RESUMO
RESUMO

Objetivo:

Avaliar o efeito da cirrose na camada de fibras nervosas da retina e na espessura da coroide através da tomografia de coerência óptica com imagem de profundidade aprimorada.

Métodos:

Este estudo transversal, de único centro, foi realizado no departamento de Oftalmologia da Universidade Bulent Ecevit com a participação do departamento de medicina interna em gtastroenterologia. Os pacientes que foram tratados com o diagnóstico de cirrose (n = 75) foram examinados na clínica da oftalmologia. Foram incluídos pacientes correspondentes em idade e sexo (n = 50) que fossem saudáveis e possuíssem o critério de inclusão exigido pelo estudo. Realização de exame oftalmológico completo acuidade visual com tabela de Snellen, a medida da pressão intraocular com tonometria de aplanação, biomicroscopia do segmento anterior e posterior, gonioscopia, medida do comprimento axial, exame de campo visual, camada de fibras nervosas da retina, macular central e medidas de espessura de coroide.

Resultados:

A diferença entre os valores de pressão intraocular não foram estatisticamente significativos entre os grupos cirrótico e controle (p=0,843). Entretanto, a espessura da camada de fibras nervosas da retina foi significativamente mais fina no grupo cirrótico em todas as regiões (p=0,001) e a espessura subfoveal da coroide também foi significativamente mais fina no grupo cirrótico (p=0,001). Além disso, a espessura macular central do grupo cirrótico foi significativamente mais grossa do que no grupo de controle (p=0,001).

Conclusão:

Por fim, as espessuras das camadas de fibras nervosas da retina e subfoveal da coroide foram significativamente mais finas nos pacientes com cirrose.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Choroid / Tomography, Optical Coherence / Liver Cirrhosis / Macula Lutea / Nerve Fibers Type of study: Controlled clinical trial / Observational study / Prevalence study / Risk factors Limits: Female / Humans / Male Language: English Journal: Rev. bras. oftalmol Journal subject: Ophthalmology Year: 2015 Type: Article Affiliation country: Turkey Institution/Affiliation country: Bülent Ecevit University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Choroid / Tomography, Optical Coherence / Liver Cirrhosis / Macula Lutea / Nerve Fibers Type of study: Controlled clinical trial / Observational study / Prevalence study / Risk factors Limits: Female / Humans / Male Language: English Journal: Rev. bras. oftalmol Journal subject: Ophthalmology Year: 2015 Type: Article Affiliation country: Turkey Institution/Affiliation country: Bülent Ecevit University/TR