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Antinociceptive activity of the extract of Erythroxylum caatingae / Actividad antinociceptiva del extracto de Erythroxylum caatingae
Leite Maia, Ana Karina; Bezerra de Queiroz, Ronaldo; Vilar da Fonsêca, Diogo; Silveira Pinho, André; Golzio Dos Santos, Sócrates; Lima de Alencar, Jacicarlos; Fechine Tavares, Josean; Nobréga De Almeida, Reinaldo; Clébia Soares Lima de Morais, Liana.
  • Leite Maia, Ana Karina; Federal University of Paraiba-UFPB. Department of Physiology and Pathology Holanda. João Pessoa. BR
  • Bezerra de Queiroz, Ronaldo; Federal University of Paraiba-UFPB. Department of Physiology and Pathology. João Pessoa. BR
  • Vilar da Fonsêca, Diogo; Federal University of Paraiba-UFPB. Department of Physiology and Pathology. João Pessoa. BR
  • Silveira Pinho, André; Federal University of Paraiba-UFPB. Department of Physiology and Pathology. João Pessoa. BR
  • Golzio Dos Santos, Sócrates; Federal University of Paraiba-UFPB. Department of Pharmaceutical Sciences. João Pessoa. BR
  • Lima de Alencar, Jacicarlos; Federal University of Paraiba-UFPB. Department of Internal Medicine. João Pessoa. BR
  • Fechine Tavares, Josean; Federal University of Paraiba-UFPB. Department of Pharmaceutical Sciences. João Pessoa. BR
  • Nobréga De Almeida, Reinaldo; Federal University of Paraiba-UFPB. Department of Physiology and Pathology. João Pessoa. BR
  • Clébia Soares Lima de Morais, Liana; Federal University of Paraiba-UFPB. Department of Physiology and Pathology. João Pessoa. BR
Bol. latinoam. Caribe plantas med. aromát ; 13(2): 152-162, mar. 2014. ilus, tab
Article in English | LILACS | ID: lil-767358
ABSTRACT
The genus Erythoxylum plants are popularly used as anti-inflammatory, anti-bacterial, and diuretic agentes, and for treating of respiratory problems. This study investigated the antinociceptive activity of methanolic extract of Erythroxylum caatingae (EcME) in chemical (formalin test and acetic acid test) and thermal models (hot plate test) of nociception. Intraperitoneal pre-treatment with EcME reduced the number of abdominal contortions and the licking time in the second phase of the formalin test. EcME did not show a significant effect in the hot plate test, rota-rod test, and the elevated plus maze test. These findings indicate that the antinociceptive activity of EcME is not because of a depressor effect on the central nervous system, and EcME is not a muscle relaxant. Nevertheless, Erythroxylum caatingae demonstrated peripheral antinociceptive activity, which confirms its popular use and contributes to the scientific knowledge of the species.
RESUMEN
El género Erythoxylum es popularmente utilizado como agente anti-inflamatorio, antibacteriano y para el tratamiento de problemas respiratorios. Este estudio tiene como objetivo investigar la actividad antinociceptiva del extracto metanólico Erythroxylum caatingae (EcME), utilizando modelos químicos (prueba de la formalina y prueba de ácido acético) y térmico (prueba de la placa caliente) de nocicepción. El pretratamiento EcME por la vía intraperitoneal (i.p.), fue capaz de reducir el número de contorsiones abdominales y el tiempo de lamida en la segunda fase del test de formalina. EcME no tuvo efecto significativo en el test de la placa caliente, Rota-Rod y Laberinto en Cruz Elevado, mostrando que el efecto antinociceptivo no está relacionado con un efecto depresor del sistema nervioso central o miorelajante. Los datos experimentales muestran que Erythroxylum caatingae posee una actividad antinociceptiva periférica que confirma su uso popular, contribuyendo para el conocimiento científico de la especie.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Erythroxylaceae / Analgesics Type of study: Prognostic study Limits: Animals Language: English Journal: Bol. latinoam. Caribe plantas med. aromát Journal subject: Botany / Medicine / Plantas Medicinais / Terapias Complementares Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Paraiba-UFPB/BR

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Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Erythroxylaceae / Analgesics Type of study: Prognostic study Limits: Animals Language: English Journal: Bol. latinoam. Caribe plantas med. aromát Journal subject: Botany / Medicine / Plantas Medicinais / Terapias Complementares Year: 2014 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Paraiba-UFPB/BR