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Rutin ameliorates methotrexate induced hepatic injury in rats
Erdogan, Esra; Ilgaz, Yasin; Gurgor, Pinar Naile; Oztas, Yesim; Topal, Turgut; Oztas, Emin.
  • Erdogan, Esra; Gulhane Military Medical Academy. Ankara. TR
  • Ilgaz, Yasin; Gulhane Military Medical Academy. Ankara. TR
  • Gurgor, Pinar Naile; Gulhane Military Medical Academy. Ankara. TR
  • Oztas, Yesim; Gulhane Military Medical Academy. Ankara. TR
  • Topal, Turgut; Gulhane Military Medical Academy. Ankara. TR
  • Oztas, Emin; Gulhane Military Medical Academy. Ankara. TR
Acta cir. bras ; 30(11): 778-784, Nov. 2015. tab, graf
Article in English | LILACS | ID: lil-767597
ABSTRACT

PURPOSE:

To investigate the possible protective effect of rutin on methotrexate induced hepatotoxicity in rats.

METHODS:

Twenty-two rats were divided into three experimental groups; Control-saline, Mtx, Mtx+Rutin. Hepatic tissue was taken for histological assessment and biochemical assays. Oxidative stress parameters malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were investigated. Liver markers aspartate aminotransferase (AST), alanine aminotransferase (ALT) were analyzed in serum.

RESULTS:

Mtx+Rutin group showed lower histological injury compared to Mtx group, MDA and ALT levels were increased, while SOD and GSH-Px were decreased in Mtx group compared with Control-saline group. MDA and ALT levels were increased, while SOD and GSH-Px were decreased in Mtx group, compared with Mtx +Rutin group. Serum AST levels were similar among the groups.

CONCLUSION:

Rutin may be a potential adjuvant drug to reduce the hepatic side effects observed during Mtx therapy for various clinical conditions.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Rutin / Methotrexate / Chemical and Drug Induced Liver Injury / Immunosuppressive Agents Type of study: Evaluation studies Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2015 Type: Article Affiliation country: Turkey Institution/Affiliation country: Gulhane Military Medical Academy/TR

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Full text: Available Index: LILACS (Americas) Main subject: Rutin / Methotrexate / Chemical and Drug Induced Liver Injury / Immunosuppressive Agents Type of study: Evaluation studies Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2015 Type: Article Affiliation country: Turkey Institution/Affiliation country: Gulhane Military Medical Academy/TR