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Comparison between hemosiderin and Technetium-99 in sentinel lymph node biopsy in human breast cancer
Vasques, Paulo Henrique Diógenes; Alves, Mayara Maia; Aquino, Ranniere Gurgel Furtado de; Torres, Roberto Vitor Almeida; Bezerra, José Lucas Martins; Brasileiro, Luis Porto; Pinheiro, Luiz Gonzaga Porto.
  • Vasques, Paulo Henrique Diógenes; Universidade Federal do Ceará. Department of Surgery. Fortaleza. BR
  • Alves, Mayara Maia; Universidade Federal do Ceará. Department of Surgery. Fortaleza. BR
  • Aquino, Ranniere Gurgel Furtado de; Universidade Federal do Ceará. Department of Surgery. Fortaleza. BR
  • Torres, Roberto Vitor Almeida; Universidade Federal do Ceará. Department of Surgery. Fortaleza. BR
  • Bezerra, José Lucas Martins; Universidade Federal do Ceará. Department of Surgery. Fortaleza. BR
  • Brasileiro, Luis Porto; Universidade Federal do Ceará. Department of Surgery. Fortaleza. BR
  • Pinheiro, Luiz Gonzaga Porto; Universidade Federal do Ceará. Department of Surgery. Fortaleza. BR
Acta cir. bras ; 30(11): 785-790, Nov. 2015. tab, graf
Article in English | LILACS | ID: lil-767598
ABSTRACT

PURPOSE:

To assess the safety and potential equivalence of the use of hemosiderin compared to the Technetium-99 in sentinel lymph node biopsy in human breast cancer.

METHODS:

Non-random sample of 14 volunteer women diagnosed with breast cancer with primary tumors (T1/T2) and clinically tumor-free axilla were submitted to the identification of sentinel lymph node using hemosiderin obtained from autologous blood injected in the periareolar region 24h before surgery on an outpatient basis. Patients received preoperative subareolar intradermal injection of Technetium-99 in the immediate preoperative period. Patients were submitted to sentinel lymph node biopsy, with incision in the axillary fold guided by Gamma-Probe, dissection by planes until the identification of the point of maximum uptake of Technetium-99, identifying the marked nodes and their colors. All surgical specimens were sent for pathological and immunohistochemical study.

RESULTS:

The results showed no evidence of side effects and/or allergic and non-allergic reactions in patients submitted to SLNB with hemosiderin. The SLN identification rate per patient was 100%. SLNB identification rate per patient with hemosiderin was the same as that of Technetium, with a concordance rate of 100% between the methods.

CONCLUSION:

Hemosiderin is a safe dye that is equivalent to Technetium in breast sentinel lymph node biopsy.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Breast Neoplasms / Carcinoma / Technetium / Sentinel Lymph Node Biopsy / Hemosiderin Type of study: Observational study / Prognostic study Limits: Adult / Aged / Aged80 / Female / Humans Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Ceará/BR

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Full text: Available Index: LILACS (Americas) Main subject: Breast Neoplasms / Carcinoma / Technetium / Sentinel Lymph Node Biopsy / Hemosiderin Type of study: Observational study / Prognostic study Limits: Adult / Aged / Aged80 / Female / Humans Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Ceará/BR