Effect of alpha-7 nicotinic acetylcholine receptor activation on beta-amyloid induced recognition memory impairment. Possible role of neurovascular function
Acta cir. bras
;
30(11): 736-742, Nov. 2015. graf
Article
in English
| LILACS
| ID: lil-767603
ABSTRACT
PURPOSE:
To evaluate the effects of PHA-543613 (α7-nAChR agonist) and galantamine (acetylcholinesterase inhibitor (AChEI)) on recognition memory and neurovascular coupling (NVC) response in beta-amyloid (Aβ) 25-35-treated mice.METHODS:
PHA-543613 (1 mg/kg, i.p.), and galantamine (3 mg/kg, s.c.), effects were tested in Aβ25-35 mice model of AD. α7-nAChR antagonist, methyllycaconitine (MLA) (1 mg/kg, i.p.), was used for evaluation of receptor blockade effects. Recognition memory in animals was assessed by the novel object recognition (NOR) task. NVC response was analyzed by laser-doppler flow meter in barrel cortex by whisker stimulation method.RESULTS:
Both, PHA-543613 and galantamine improve recognition memory in Aβ-treated animals. However, the advantageous effects of PHA-543613 were significantly higher than galantamine. Also, pretreatment with MLA reversed both galantamine and PHA-543613 effects on NOR. Impaired NVC response in AD animals was improved by PHA-543613 and galantamine. However, MLA pretreatment disrupts this function.CONCLUSION:
Activation of α7-nAChR improved recognition memory possible through enhancement of neurovascular response in Alzheimer's disease in animals.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Peptide Fragments
/
Quinuclidines
/
Cholinesterase Inhibitors
/
Amyloid beta-Peptides
/
Bridged Bicyclo Compounds, Heterocyclic
/
Neurovascular Coupling
/
Galantamine
/
Memory Disorders
Type of study:
Evaluation studies
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2015
Type:
Article
/
Project document
Affiliation country:
Iran
Institution/Affiliation country:
Tabriz University of Medical Sciences/IR
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