Antimicrobial resistance profiles and oxacillinase genes in carbapenem-resistant Acinetobacter baumannii isolated from hospitalized patients in Santa Catarina, Brazil
Rev. Soc. Bras. Med. Trop
;
48(6): 699-705, Nov.-Dec. 2015. tab, graf
Article
in English
| LILACS
| ID: lil-767825
ABSTRACT
Abstract INTRODUCTION:
Carbapenems are the therapy of choice for treating severe infections caused by the Acinetobacter calcoaceticus-Acinetobacter baumannii complex. We aimed to assess the prevalence and antimicrobial susceptibility profiles of producers of distinct oxacillinases among nosocomial isolates of the A. calcoaceticus-A. baumannii complex in a 249-bed general hospital located in Joinville, Southern Brazil.METHODS:
Of the 139 A. baumannii clinical isolates with reduced susceptibility to carbapenems between 2010 and 2013, 118 isolates from varying anatomical sites and hospital sectors were selected for genotypic analysis. Five families of genes encoding oxacillinases, namely blaOXA-23-like, blaOXA-24-like, blaOXA-51-like, blaOXA-58-like, and blaOXA-143-like, wereinvestigated by multiplex polymerase chain reaction (PCR).RESULTS:
Most (87.3%) isolates simultaneously carried the blaOXA-23-likeand blaOXA-51-likegenes, whereas three (2.5%) isolates harbored only blaOXA-51-likeones. The circulation of carbapenem-resistant isolates increased during the study period from none in 2010, to 22 in 2011, 64 in 2012, and 53 in 2013.CONCLUSIONS:
Isolates carrying the blaOXA-23-likeand blaOXA-51-likegenes were widely distributed in the hospital investigated. Because of the worsening scenario, the implementation of preventive measures and effective barriers is needed.
Full text:
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Index:
LILACS (Americas)
Main subject:
Beta-Lactamases
/
Acinetobacter Infections
/
Carbapenems
/
Cross Infection
/
Acinetobacter baumannii
/
Anti-Bacterial Agents
Type of study:
Risk factors
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2015
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hospital Regional Hans Dieter Schmidt/BR
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