An Aggressive Plasmablastic Lymphoma of the Oral Cavity as Primary Manifestation of Acquired Immunodeficiency Syndrome: Case Report and Literature Review
Int. arch. otorhinolaryngol. (Impr.)
; 19(4): 354-358, Oct.-Dec. 2015. ilus
Article
in En
| LILACS
| ID: lil-768335
Responsible library:
BR1.1
ABSTRACT
Introduction Plasmablastic lymphoma is a rare entity that was first described in the jaws and the oral cavity of patients with human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS). Plasmablastic lymphoma is considered as a diffuse, large, B-cell lymphoma with a unique phenotype and a predilection for the oral cavity. Objectives The authors describe a case of an aggressive plasmablastic lymphoma of the oral cavity as the primary manifestation of AIDS. Resumed We report a case of plasmablastic lymphoma involving only the oral cavity as the first manifestation of AIDS. Diagnosis was confirmed by the oral lesion biopsy and the histopathologic examination that showed a dense infiltrate composed of atypical lymphocytes with numerous plasmocytes that expressed the plasma cell markers MUM-1 and CD138 and that were negative for the B-cell markers CD3, CD20, and CD45. Immunohistochemical and in situ hybridization revealed the Epstein-Barr virus genome in the atypical cells. Polymerase chain reaction was also positive for human herpesvirus-8 RNA. Conclusion The HIV serologic status should be evaluated in all patients with plasmablastic lymphoma of the oral cavity or extraoral sites.(AU)
Key words
Full text:
1
Index:
LILACS
Main subject:
Acquired Immunodeficiency Syndrome
/
HIV
/
Plasmablastic Lymphoma
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Int. arch. otorhinolaryngol. (Impr.)
Journal subject:
OTORRINOLARINGOLOGIA
Year:
2015
Type:
Article