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Efficacy and safety of a single dose pentamidine (7mg/kg) for patients with cutaneous leishmaniasis caused by L. guyanensis: a pilot study
Gadelha, Ellen Priscilla Nunes; Talhari, Sinésio; Guerra, Jorge Augusto de Oliveira; Neves, Leandro Ourives; Talhari, Carolina; Gontijo, Bernardo; Silva Junior, Roberto Moreira da; Talhari, Anette Chrusciak.
  • Gadelha, Ellen Priscilla Nunes; Fundação de Medicina Tropical do Amazonas Dr. Heitor Vieira Dourado. Manaus. BR
  • Talhari, Sinésio; Fundação de Medicina Tropical do Amazonas Dr. Heitor Vieira Dourado. Manaus. BR
  • Guerra, Jorge Augusto de Oliveira; Fundação de Medicina Tropical do Amazonas Dr. Heitor Vieira Dourado. Manaus. BR
  • Neves, Leandro Ourives; Fundação de Medicina Tropical do Amazonas Dr. Heitor Vieira Dourado. Manaus. BR
  • Talhari, Carolina; Fundação de Medicina Tropical do Amazonas Dr. Heitor Vieira Dourado. Manaus. BR
  • Gontijo, Bernardo; Fundação de Medicina Tropical do Amazonas Dr. Heitor Vieira Dourado. Manaus. BR
  • Silva Junior, Roberto Moreira da; Fundação de Medicina Tropical do Amazonas Dr. Heitor Vieira Dourado. Manaus. BR
  • Talhari, Anette Chrusciak; Fundação de Medicina Tropical do Amazonas Dr. Heitor Vieira Dourado. Manaus. BR
An. bras. dermatol ; 90(6): 807-813, Nov.-Dec. 2015. tab, graf
Article in English | LILACS | ID: lil-769514
ABSTRACT
Abstract

BACKGROUND:

There have been few studies on pentamidine in the Americas; and there is no consensus regarding the dose that should be applied.

OBJECTIVES:

To evaluate the use of pentamidine in a single dose to treat cutaneous leishmaniasis.

METHODS:

Clinical trial of phase II pilot study with 20 patients. Pentamidine was used at a dose of 7 mg/kg, in a single dose. Safety and adverse effects were also assessed. Patients were reviewed one, two, and six months after the end of treatments.

RESULTS:

there was no difference between the treatment groups in relation to gender, age, number or location of the lesions. Pentamidine, applied in a single dose, obtained an effectiveness of 55%. Mild adverse events were reported by 17 (85%) patients, mainly transient pain at the site of applications (85%), while nausea (5%), malaise (5%) and dizziness (5%) were reported in one patient. No patient had sterile abscess after taking medication at a single dose of 7mg/kg.

CONCLUSIONS:

Clinical studies with larger samples of patients would enable a better clinical response of pent amidine at a single dose of 7mg, allowing the application of more powerful statistical tests, thus providing more evidences of the decrease in the effectiveness of that medication. Hence, it is important to have larger studies with new diagrams and/or new medications.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Phenyl Ethers / Benzamidines / Leishmaniasis, Cutaneous / Leishmania guyanensis / Antiprotozoal Agents Limits: Adolescent / Adult / Female / Humans / Male Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação de Medicina Tropical do Amazonas Dr. Heitor Vieira Dourado/BR

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Full text: Available Index: LILACS (Americas) Main subject: Phenyl Ethers / Benzamidines / Leishmaniasis, Cutaneous / Leishmania guyanensis / Antiprotozoal Agents Limits: Adolescent / Adult / Female / Humans / Male Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação de Medicina Tropical do Amazonas Dr. Heitor Vieira Dourado/BR