Long-term recurrence of nonmelanoma skin cancer after topical methylaminolevulinate photodynamic therapy in a dermato-oncology department
An. bras. dermatol
; 90(6): 846-850, Nov.-Dec. 2015. tab, graf
Article
in En
| LILACS
| ID: lil-769517
Responsible library:
BR1.1
ABSTRACT
Abstract BACKGROUND:
Most available studies on the efficacy of topical photodynamic therapy focus on short-to medium-term results. Long-term data are scarce.OBJECTIVE:
To evaluate the long-term efficacy of photodynamic therapy with topical methylaminolevulinate to treat Bowen's disease and basal cell carcinoma in the clinical practice setting of a dermato-oncology department.METHODS:
The study included patients diagnosed with Bowen's disease or basal cell carcinoma, and who received photodynamic therapy from 2004 to 2008. Treatment protocol and clinical follow-up were standardized. The primary endpoint was clinically observed recurrence in a previous photodynamic therapy-treated area. Descriptive and survival analyses were performed.RESULTS:
A total of 31 Bowen's disease lesions and 44 superficial basal cell carcinoma were treated, with a median follow-up of 43.5 months. Recurrence was observed in 14 Bowen's disease lesions (53.8%) and in 11 superficial basal cell carcinoma (33.3%). Significantly higher estimates for recurrence rates were found in patients with Bowen's disease (p=0.0036) or those aged under 58 years (p=0.039). The risk of recurrence was higher in patients with Bowen's disease than in those with superficial basal cell carcinoma and younger patients.CONCLUSIONS:
Recurrence should be considered when choosing to treat non-melanoma skin cancer with photodynamic therapy. Younger age and Bowen's disease were independent predictors for long-term recurrence, suggesting the need to establish an extended period of follow-up for this subset of patients.Key words
Full text:
1
Index:
LILACS
Main subject:
Photochemotherapy
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Skin Neoplasms
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Bowen's Disease
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Carcinoma, Basal Cell
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Photosensitizing Agents
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Aminolevulinic Acid
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Neoplasm Recurrence, Local
Type of study:
Etiology_studies
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Guideline
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limits:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Language:
En
Journal:
An. bras. dermatol
Journal subject:
DERMATOLOGIA
Year:
2015
Type:
Article