Adenosine: an endogenous mediator in the pathogenesis of psoriasis
An. bras. dermatol
;
90(6): 862-867, Nov.-Dec. 2015. graf
Article
in English
| LILACS
| ID: lil-769527
ABSTRACT
Abstract It is known that inflammatory and immune responses protect us from the invasion of micro-organisms and eliminate "wastes" from the injured sites, but they may also be responsible for significant tissue damage. Adenosine, as a purine nucleoside, which is produced in inflamed or injured sites, fulfills its role in limiting tissue damage. Although, it may have a pleiotropic effect, which signals it with a proinflammatory state in certain situations, it can be considered a potent anti-inflammatory mediator. The effects of adenosine, which acts through its receptors on T cell, on mast cell and macrophages, on endothelial cells, on neutrophils and dendritic cells, as they indicate TNF-alpha and cytokines, show that this mediator has a central role in the pathogenesis of psoriasis. The way it acts in psoriasis will be reviewed in this study.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Psoriasis
/
Adenosine
Type of study:
Etiology study
Limits:
Humans
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2015
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Caxias do Sul/BR
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