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Impaired bone mineral accrual in prepubertal HIV-infected children: a cohort study
Palchetti, Cecília Zanin; Szejnfeld, Vera Lúcia; Succi, Regina Célia de Menezes; Patin, Rose Vega; Teixeira, Patrícia Fonseca; Machado, Daisy Maria; Oliveira, Fernanda Luisa Ceragioli.
  • Palchetti, Cecília Zanin; Universidade Federal de São Paulo. Escola Paulista de Medicina. Department of Pediatrics. São Paulo. BR
  • Szejnfeld, Vera Lúcia; Universidade Federal de São Paulo. Escola Paulista de Medicina. Department of Pediatrics. São Paulo. BR
  • Succi, Regina Célia de Menezes; Universidade Federal de São Paulo. Escola Paulista de Medicina. Department of Pediatrics. São Paulo. BR
  • Patin, Rose Vega; Universidade Federal de São Paulo. Escola Paulista de Medicina. Department of Pediatrics. São Paulo. BR
  • Teixeira, Patrícia Fonseca; Universidade Federal de São Paulo. Escola Paulista de Medicina. Department of Pediatrics. São Paulo. BR
  • Machado, Daisy Maria; Universidade Federal de São Paulo. Escola Paulista de Medicina. Department of Pediatrics. São Paulo. BR
  • Oliveira, Fernanda Luisa Ceragioli; Universidade Federal de São Paulo. Escola Paulista de Medicina. Department of Pediatrics. São Paulo. BR
Braz. j. infect. dis ; 19(6): 623-630, Nov.-Dec. 2015. tab
Article in English | LILACS | ID: lil-769623
ABSTRACT
ABSTRACT

OBJECTIVE:

To evaluate bone mass accrual and determine the influence of clinical, anthropometric, dietary and biochemical parameters on bone mass.

METHODS:

A cohort study including 35 prepubertal HIV-infected children, between 7 and 12 years, attended at a referral center. At time 1 (T1) and time 2 (T2), patients were assessed according to clinical, anthropometric, dietary, biochemical parameters and bone mineral density (BMD). At T2, patients were divided into prepubertal and pubertal.

RESULTS:

Despite the increase in bone mass absolute values, there was no improvement in lumbar spine BMD (LSBMD) Z-score (p = 0.512) and worsening in total body BMD (TBMD) Z-score (p = 0.040). Pubertal patients (n = 19) showed higher bone mineral content (BMC) (p = 0.001), TBMD (p = 0.006) and LSBMD (p = 0.002) compared to prepubertal patients. After multivariate linear regression analysis, the predictors of bone mass in T1 were age, BMI and HAZ-scores for BMC; BMI Z-score, adequate serum magnesium concentration and dietary calcium intake for TBMD; adequate serum concentration of magnesium, BMI and HAZ-scores for LSBMD. In T2, age, total body fat and lean body mass (kg) for BMC; BMI Z-score and puberty for TBMD; dietary fat intake, BMI Z-score for BMD and puberty for LSBMD.

CONCLUSION:

HIV-infected children have compromised bone mass and the presence of puberty seems to provide suitability of these parameters. Adequate intake of calcium and fat appears to be protective for proper bone mass accumulation factor, as well as monitoring nutritional status and serum magnesium concentration.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Body Composition / Bone Density / HIV Infections Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Child / Female / Humans / Male Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Body Composition / Bone Density / HIV Infections Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Child / Female / Humans / Male Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de São Paulo/BR