Sphingosine Kinase 1 urothelial expression is increased in patients with neurogenic detrusor overactivity
Int. braz. j. urol
;
41(6): 1141-1147, Nov.-Dec. 2015. tab, graf
Article
in English
| LILACS
| ID: lil-769751
ABSTRACT
Objectives:
To evaluate the expression of sphingosine kinase 1 (SPK1) in the bladder wall in patients with neurogenic lower urinary tract dysfunction and its association with clinical, urodynamic and pathological features. Materials andMethods:
The expression of SPK1 was studied in bladder wall specimens obtained from cystectomy using immunohistochemistry in ten patients with spinal cord injury (n=8) or multiple sclerosis (n=2) with urodynamically proven neuropathic bladder dysfunction, and in controls (n=5). Inflammation and fibrosis were analysed with histological criteria and SPK1 expression was determined by individual immunohistochemical staining.Results:
Significant increased SPK1 urothelial immunoreactivity was shown in patients compared to control group (p=0.03). By contrast, SPK1 immunoreactivity in patients was significantly decreased in the sub-urothelium, muscles and nerves, p=0.02; 0.01 and 0.003, respectively. Patients with neurogenic detrusor overactivity (NDO) had higher SPK1 urothelium expression than those without any DO (p=0.04).Conclusions:
SPK1 is expressed in the human bladder wall, specifically the urothelium, in bladder specimens from patients with NDO. The role of SPK1 in the pathophysiology of NDO needs further elucidation.
Full text:
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Index:
LILACS (Americas)
Main subject:
Spinal Cord Injuries
/
Phosphotransferases (Alcohol Group Acceptor)
/
Urinary Bladder, Overactive
Type of study:
Etiology study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Int. braz. j. urol
Journal subject:
Urology
Year:
2015
Type:
Article
Affiliation country:
France
Institution/Affiliation country:
CHU Rangueil/FR
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