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Evaluation of acetylcholinesterase inhibitory activity of Brazilian red macroalgae organic extracts
Machado, Levi P.; Carvalho, Luciana R.; Young, Maria Cláudia M.; Cardoso-Lopes, Elaine M.; Centeno, Danilo C.; Zambotti-Villela, Leonardo; Colepicolo, Pio; Yokoya, Nair S..
Affiliation
  • Machado, Levi P.; Instituto de Botânica. Núcleo de Pesquisa em Ficologia. São Paulo. BR
  • Carvalho, Luciana R.; Instituto de Botânica. Núcleo de Pesquisa em Ficologia. São Paulo. BR
  • Young, Maria Cláudia M.; Instituto de Botânica. Núcleo de Pesquisa em Ficologia. São Paulo. BR
  • Cardoso-Lopes, Elaine M.; Instituto de Botânica. Núcleo de Pesquisa em Ficologia. São Paulo. BR
  • Centeno, Danilo C.; Instituto de Botânica. Núcleo de Pesquisa em Ficologia. São Paulo. BR
  • Zambotti-Villela, Leonardo; Instituto de Botânica. Núcleo de Pesquisa em Ficologia. São Paulo. BR
  • Colepicolo, Pio; Instituto de Botânica. Núcleo de Pesquisa em Ficologia. São Paulo. BR
  • Yokoya, Nair S.; Instituto de Botânica. Núcleo de Pesquisa em Ficologia. São Paulo. BR
Rev. bras. farmacogn ; 25(6): 657-662, Nov.-Dec. 2015. tab, graf
Article in En | LILACS | ID: lil-769944
Responsible library: BR1.1
ABSTRACT
Abstract Alzheimer's disease affects nearly 36.5 million people worldwide, and acetylcholinesterase inhibition is currently considered the main therapeutic strategy against it. Seaweed biodiversity in Brazil represents one of the most important sources of biologically active compounds for applications in phytotherapy. Accordingly, this study aimed to carry out a quantitative and qualitative assessment of Hypnea musciformis (Wulfen) J.V. Lamouroux, Ochtodes secundiramea (Montagne) M.A. Howe, and Pterocladiella capillacea (S.G. Gmelin) Santelices & Hommersand (Rhodophyta) in order to determine the AChE effects from their extracts. As a matter of fact, the O. secundiramea extract showed 48% acetylcholinesterase inhibition at 400 μg/ml. The chemical composition of the bioactive fraction was determined by gas chromatography–mass spectrometry (GC–MS); this fraction is solely composed of halogenated monoterpenes, therefore allowing assignment of acetylcholinesterase inhibition activity to them.
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Full text: 1 Index: LILACS Type of study: Qualitative_research Country/Region as subject: America do sul / Brasil Language: En Journal: Rev. bras. farmacogn Journal subject: FARMACIA Year: 2015 Type: Article
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Full text: 1 Index: LILACS Type of study: Qualitative_research Country/Region as subject: America do sul / Brasil Language: En Journal: Rev. bras. farmacogn Journal subject: FARMACIA Year: 2015 Type: Article