Your browser doesn't support javascript.
loading
Association of interleukin-10 levels with age of onset and duration of illness in patients with major depressive disorder
Gazal, Marta; Jansen, Karen; Souza, Luciano D.; Oses, Jean P.; Magalhães, Pedro V.; Pinheiro, Ricardo; Ghisleni, Gabriele; Quevedo, Luciana; Kaster, Manuella P.; Kapczinski, Flávio; Silva, Ricardo A. da.
  • Gazal, Marta; Pontifícia Universidade Católica do Rio Grande do Sul. Graduate Program in Cellular and Molecular Biology. Porto Alegre. BR
  • Jansen, Karen; Pontifícia Universidade Católica do Rio Grande do Sul. Graduate Program in Cellular and Molecular Biology. Porto Alegre. BR
  • Souza, Luciano D.; Pontifícia Universidade Católica do Rio Grande do Sul. Graduate Program in Cellular and Molecular Biology. Porto Alegre. BR
  • Oses, Jean P.; Pontifícia Universidade Católica do Rio Grande do Sul. Graduate Program in Cellular and Molecular Biology. Porto Alegre. BR
  • Magalhães, Pedro V.; Pontifícia Universidade Católica do Rio Grande do Sul. Graduate Program in Cellular and Molecular Biology. Porto Alegre. BR
  • Pinheiro, Ricardo; Pontifícia Universidade Católica do Rio Grande do Sul. Graduate Program in Cellular and Molecular Biology. Porto Alegre. BR
  • Ghisleni, Gabriele; Pontifícia Universidade Católica do Rio Grande do Sul. Graduate Program in Cellular and Molecular Biology. Porto Alegre. BR
  • Quevedo, Luciana; Pontifícia Universidade Católica do Rio Grande do Sul. Graduate Program in Cellular and Molecular Biology. Porto Alegre. BR
  • Kaster, Manuella P.; Pontifícia Universidade Católica do Rio Grande do Sul. Graduate Program in Cellular and Molecular Biology. Porto Alegre. BR
  • Kapczinski, Flávio; Pontifícia Universidade Católica do Rio Grande do Sul. Graduate Program in Cellular and Molecular Biology. Porto Alegre. BR
  • Silva, Ricardo A. da; Pontifícia Universidade Católica do Rio Grande do Sul. Graduate Program in Cellular and Molecular Biology. Porto Alegre. BR
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 37(4): 296-302, Oct.-Dec. 2015. tab, graf
Article in English | LILACS | ID: lil-770004
ABSTRACT

Objective:

To investigate peripheral levels of interleukin-10 (IL-10) in patients with major depressive disorder (MDD) and bipolar disorder (BD) and evaluate the relationship between IL-10, age of disease onset, and duration of illness.

Methods:

Case-control study nested in a population-based cohort of 231 individuals (age 18-24 years) living in Pelotas, state of Rio Grande do Sul, Brazil. Participants were screened for psychopathology using the Mini-International Neuropsychiatric Interview (MINI) and the Structured Clinical Interview for DSM-IV (SCID-I). Serum IL-10 was measured using commercially available immunoassay kits.

Results:

Peripheral levels of IL-10 were not significantly different in individuals with MDD or BD as compared to controls. However, higher IL-10 levels were found in MDD patients with a later disease onset as compared with controls or early-onset patients. In addition, IL-10 levels correlated negatively with illness duration in the MDD group. In the BD group, age of onset and duration of illness did not correlate with IL-10 levels.

Conclusion:

Higher levels of IL-10 are correlated with late onset of MDD symptoms. Moreover, levels of this cytokine might decrease with disease progression, suggesting that an anti-inflammatory balance may be involved in the onset of depressive symptoms and disease progression in susceptible individuals.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Bipolar Disorder / Depressive Disorder, Major Type of study: Observational study / Qualitative research / Risk factors Limits: Adolescent / Adult / Female / Humans / Male Language: English Journal: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Journal subject: Psychiatry Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Pontifícia Universidade Católica do Rio Grande do Sul/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Bipolar Disorder / Depressive Disorder, Major Type of study: Observational study / Qualitative research / Risk factors Limits: Adolescent / Adult / Female / Humans / Male Language: English Journal: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Journal subject: Psychiatry Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Pontifícia Universidade Católica do Rio Grande do Sul/BR