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Leucoencefalopatía tóxica fatal: tres casos asociados al consumo de pasta base de cocaína / Fatal toxic leukoencephalopathy associated with consumption of pasta base of cocaine: Report of three cases
Cartier R, Luis; González L, Daniela; Harán D, Jorge.
  • Cartier R, Luis; Universidad de Chile. Facultad de Medicina. Departamento Ciencias Neurológicas. CL
  • González L, Daniela; Universidad de Chile. Facultad de Medicina. Departamento Ciencias Neurológicas. CL
  • Harán D, Jorge; Universidad de Chile. Facultad de Medicina. Departamento Ciencias Neurológicas. CL
Rev. méd. Chile ; 143(11): 1484-1489, nov. 2015. ilus
Article in Spanish | LILACS | ID: lil-771737
ABSTRACT
The prevalence of drug-associated toxic encephalopathy is unknown, but it is an uncommon condition. Toxic leukoencephalopathy was described associated with heroin consumption, it has been less commonly described with the use of cocaine and there are no reports of its association with consumption pasta base of cocaine (PBC). We report two females aged 31 years and a male aged 19 years, consumers of PBC who developed a fatal toxic leukoencephalopathy. They initiated their disease with severe and persistent headache, sequential focal neurologic deficits and a progressive impairment of consciousness that culminated with their death. Laboratory parameters such as blood count, cerebrospinal fluid analyses or infectious biological indices were normal. MRI showed multifocal lesions in brain white matter of both hemispheres confirming the leukoencephalopathy. There was no response to the use of methylprednisolone.
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Full text: Available Index: LILACS (Americas) Main subject: Cocaine / Leukoencephalopathies Type of study: Diagnostic study / Etiology study / Risk factors Limits: Adult / Female / Humans / Male Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2015 Type: Article Affiliation country: Chile Institution/Affiliation country: Universidad de Chile/CL

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Full text: Available Index: LILACS (Americas) Main subject: Cocaine / Leukoencephalopathies Type of study: Diagnostic study / Etiology study / Risk factors Limits: Adult / Female / Humans / Male Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2015 Type: Article Affiliation country: Chile Institution/Affiliation country: Universidad de Chile/CL