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Remote limb ischemic post-conditioning attenuates ischemia-reperfusion injury in rat skin flapby limiting oxidative stress
Zhang, Yi; Xu, Hua; Wang, Tao; He, Jinguang; Wei, Jiao; Wang, Tingliang; Dong, Jiasheng.
Affiliation
  • Zhang, Yi; Shanghai Jiao Tong University. School of Medicine. CN
  • Xu, Hua; Shanghai Jiao Tong University. School of Medicine. CN
  • Wang, Tao; Shanghai Jiao Tong University. School of Medicine. CN
  • He, Jinguang; Shanghai Jiao Tong University. School of Medicine. CN
  • Wei, Jiao; Shanghai Jiao Tong University. School of Medicine. CN
  • Wang, Tingliang; Shanghai Jiao Tong University. School of Medicine. CN
  • Dong, Jiasheng; Shanghai Jiao Tong University. School of Medicine. CN
Acta cir. bras ; 31(1): 15-21, Jan. 2016. tab, graf
Article in En | LILACS | ID: lil-771850
Responsible library: BR1.1
ABSTRACT

PURPOSE:

To investigate the effect of remote ischemic post-conditioning (RIPoC) against ischemia-reperfusion (I/R) injury on flaps of rats.

METHODS:

Sprague-Dawley rats were randomized into the Sham, Control, RIPoC1 and RIPoC2 groups. All the animals were submitted to a 5×4 cm superficial inferior epigastric artery flap. Eight hours of flap ischemia was induced and two protocols of limb RIPoC were applied. Tissue MDA level and SOD activity in 24-h reperfusion were assessed. Flap survival was assessed 7 days postoperatively.

RESULTS:

Compared to the Control group, the RIPoC1 group showed statistically decreased MDA level at 6-, 12-, and 24-h reperfusion (P = 0.01, P < 0.01 and P < 0.01, respectively), and statistically increased SOD activity at 12- and 24-h reperfusion (P < 0.05 and P < 0.01, respectively). Flap survival rate on the 7th day was significantly higher in the RIPoC1 group than the control group (47.9 ± 6.4 vs . 29.4 ± 7.1 %, P < 0.01).

CONCLUSION:

Three cycles of 5-min Limb remote ischemic post-conditioning rather than a single cycle of 15-min limb RIPoC has protective effect on flaps against ischemia-reperfusion injury by attenuating oxidative stress.
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Key words

Full text: 1 Index: LILACS Main subject: Surgical Flaps / Reperfusion Injury / Oxidative Stress / Ischemic Postconditioning / Dermatologic Surgical Procedures Limits: Animals Language: En Journal: Acta cir. bras Journal subject: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Year: 2016 Type: Article

Full text: 1 Index: LILACS Main subject: Surgical Flaps / Reperfusion Injury / Oxidative Stress / Ischemic Postconditioning / Dermatologic Surgical Procedures Limits: Animals Language: En Journal: Acta cir. bras Journal subject: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Year: 2016 Type: Article