Ischemic preconditioning modifies mortality and inflammatory response
Acta cir. bras
;
31(1): 1-7, Jan. 2016. graf
Article
in English
| LILACS
| ID: lil-771855
ABSTRACT
PURPOSE:
To evaluate the effect of ischemic preconditioning on mortality, inflammatory mediators and oxidative stress after intestinal ischemia and reperfusion.METHODS:
Male Wistar rats were allocated according to the period of ischemia with or without ischemic preconditioning which consist on clamping the superior mesenteric artery for 10 minutes followed by reperfusion for 10 minutes before the sustained ischemia period. Mortality was assessed in Phase 1 study, and the CINC-1, CINC-2 and MDA levels in the lungs were analyzed in Phase 2.RESULTS:
Mortality was lower in the ischemic preconditioning group subjected to 90 minutes of ischemia compared to the group without ischemic preconditioning (I-90 50% and IPC-90 15%, p=0.018), and it was lower in the ischemic preconditioning group as a whole compared to the groups without ischemic preconditioning (IPC-14% and I=30%, p=0.006). Lower levels of MDA, CINC-1, and CINC-2 were observed in the animals that were subjected to ischemic preconditioning compared to the animals that were not (MDA I-45=1.23 nmol/mg protein, and IPC-45=0.62 nmol/mg protein, p=0.0333; CINC-1 I-45=0.82 ng/mL and IPC-45=0.67 ng/mL, p=0.041; CINC-2 I-45=0.52 ng/mL and IPC-45=0.35 ng/mL, p=0.032).CONCLUSION:
Ischemic preconditioning reduces mortality, inflammatory process and oxidative stress in rats subjected to intestinal ischemia and reperfusion.
Full text:
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Index:
LILACS (Americas)
Main subject:
Reperfusion Injury
/
Oxidative Stress
/
Inflammation Mediators
/
Ischemic Preconditioning
/
Mesenteric Ischemia
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2016
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de São Paulo/BR
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