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Ischemic preconditioning modifies mortality and inflammatory response
Pinheiro, Daniel Faria de Campos; Fontes, Belchor; Shimazaki, John Kioshi; Heimbecker, Ana Maria Cattani; Jacysyn, Jacqueline de Fátima; Rasslan, Samir; Montero, Edna Frasson de Souza; Utiyama, Edivaldo Massazo.
  • Pinheiro, Daniel Faria de Campos; Universidade de São Paulo. Medical School. Department of Surgery. BR
  • Fontes, Belchor; Universidade de São Paulo. Medical School. Department of Surgery. BR
  • Shimazaki, John Kioshi; Universidade de São Paulo. Medical School. Department of Surgery. BR
  • Heimbecker, Ana Maria Cattani; Universidade de São Paulo. Medical School. Department of Surgery. BR
  • Jacysyn, Jacqueline de Fátima; Universidade de São Paulo. Medical School. Department of Surgery. BR
  • Rasslan, Samir; Universidade de São Paulo. Medical School. Department of Surgery. BR
  • Montero, Edna Frasson de Souza; Universidade de São Paulo. Medical School. Department of Surgery. BR
  • Utiyama, Edivaldo Massazo; Universidade de São Paulo. Medical School. Department of Surgery. BR
Acta cir. bras ; 31(1): 1-7, Jan. 2016. graf
Article in English | LILACS | ID: lil-771855
ABSTRACT

PURPOSE:

To evaluate the effect of ischemic preconditioning on mortality, inflammatory mediators and oxidative stress after intestinal ischemia and reperfusion.

METHODS:

Male Wistar rats were allocated according to the period of ischemia with or without ischemic preconditioning which consist on clamping the superior mesenteric artery for 10 minutes followed by reperfusion for 10 minutes before the sustained ischemia period. Mortality was assessed in Phase 1 study, and the CINC-1, CINC-2 and MDA levels in the lungs were analyzed in Phase 2.

RESULTS:

Mortality was lower in the ischemic preconditioning group subjected to 90 minutes of ischemia compared to the group without ischemic preconditioning (I-90 50% and IPC-90 15%, p=0.018), and it was lower in the ischemic preconditioning group as a whole compared to the groups without ischemic preconditioning (IPC-14% and I=30%, p=0.006). Lower levels of MDA, CINC-1, and CINC-2 were observed in the animals that were subjected to ischemic preconditioning compared to the animals that were not (MDA I-45=1.23 nmol/mg protein, and IPC-45=0.62 nmol/mg protein, p=0.0333; CINC-1 I-45=0.82 ng/mL and IPC-45=0.67 ng/mL, p=0.041; CINC-2 I-45=0.52 ng/mL and IPC-45=0.35 ng/mL, p=0.032).

CONCLUSION:

Ischemic preconditioning reduces mortality, inflammatory process and oxidative stress in rats subjected to intestinal ischemia and reperfusion.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Reperfusion Injury / Oxidative Stress / Inflammation Mediators / Ischemic Preconditioning / Mesenteric Ischemia Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Reperfusion Injury / Oxidative Stress / Inflammation Mediators / Ischemic Preconditioning / Mesenteric Ischemia Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR