Your browser doesn't support javascript.
loading
Association of the solute carrier family 11 member 1 gene polymorphisms with susceptibility to leprosy in a Brazilian sample
Brochado, Maria José Franco; Gatti, Maria Fernanda Chociay; Zago, Marco Antônio; Roselino, Ana Maria.
  • Brochado, Maria José Franco; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Hospital Universitário. Ribeirão Preto. BR
  • Gatti, Maria Fernanda Chociay; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Hospital Universitário. Ribeirão Preto. BR
  • Zago, Marco Antônio; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Hospital Universitário. Ribeirão Preto. BR
  • Roselino, Ana Maria; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Hospital Universitário. Ribeirão Preto. BR
Mem. Inst. Oswaldo Cruz ; 111(2): 101-105, Feb. 2016. tab
Article in English | LILACS | ID: lil-772613
ABSTRACT
Natural resistance-associated macrophage protein 1/solute carrier family 11 member 1 gene (Nramp1/Slc11a1) is a gene that controls the susceptibility of inbred mice to intracellular pathogens. Polymorphisms in the human Slc11a1/Nramp1 gene have been associated with host susceptibility to leprosy. This study has evaluated nine polymorphisms of the Slc11a1/Nramp1 gene [(GT)n, 274C/T, 469+14G/C, 577-18G/A, 823C/T, 1029 C/T, 1465-85G/A, 1703G/A, and 1729+55del4] in 86 leprosy patients (67 and 19 patients had the multibacillary and the paucibacillary clinical forms of the disease, respectively), and 239 healthy controls matched by age, gender, and ethnicity. The frequency of allele 2 of the (GT)n polymorphism was higher in leprosy patients [p = 0.04, odds ratio (OR) = 1.49], whereas the frequency of allele 3 was higher in the control group (p = 0.03; OR = 0.66). Patients carrying the 274T allele (p = 0.04; OR = 1.49) and TT homozygosis (p = 0.02; OR = 2.46), such as the 469+14C allele (p = 0.03; OR = 1.53) of the 274C/T and 469+14G/C polymorphisms, respectively, were more frequent in the leprosy group. The leprosy and control groups had similar frequency of the 577-18G/A, 823C/T, 1029C/T, 1465-85G/A, 1703G/A, and 1729+55del4 polymorphisms. The 274C/T polymorphism in exon 3 and the 469+14G/C polymorphism in intron 4 were associated with susceptibility to leprosy, while the allele 2 and 3 of the (GT)n polymorphism in the promoter region were associated with susceptibility and protection to leprosy, respectively.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Genetic Predisposition to Disease / Cation Transport Proteins / Leprosy Type of study: Evaluation studies / Observational study / Risk factors Limits: Adult / Aged / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Genetic Predisposition to Disease / Cation Transport Proteins / Leprosy Type of study: Evaluation studies / Observational study / Risk factors Limits: Adult / Aged / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR