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Gestation and breastfeeding in schistosomotic mothers differently modulate the immune response of adult offspring to postnatal Schistosoma mansoni infection
Santos, Patrícia d‘Emery Alves; Lorena, Virgínia Maria Barros de; Fernandes, Érica de Souza; Sales, Iana Rafaela Fernandes; Nascimento, Wheverton Ricardo Correia do; Gomes, Yara de Miranda; Albuquerque, Mônica Camelo Pessoa de Azevedo; Costa, Vlaudia Maria Assis; Souza, Valdênia Maria Oliveira de.
  • Santos, Patrícia d‘Emery Alves; Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Setor de Imunologia. Recife. BR
  • Lorena, Virgínia Maria Barros de; Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Setor de Imunologia. Recife. BR
  • Fernandes, Érica de Souza; Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Setor de Imunologia. Recife. BR
  • Sales, Iana Rafaela Fernandes; Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Setor de Imunologia. Recife. BR
  • Nascimento, Wheverton Ricardo Correia do; Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Setor de Imunologia. Recife. BR
  • Gomes, Yara de Miranda; Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Setor de Imunologia. Recife. BR
  • Albuquerque, Mônica Camelo Pessoa de Azevedo; Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Setor de Imunologia. Recife. BR
  • Costa, Vlaudia Maria Assis; Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Setor de Imunologia. Recife. BR
  • Souza, Valdênia Maria Oliveira de; Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami. Setor de Imunologia. Recife. BR
Mem. Inst. Oswaldo Cruz ; 111(2): 83-92, Feb. 2016. tab, graf
Article in English | LILACS | ID: lil-772619
ABSTRACT
Schistosoma mansoni antigens in the early life alter homologous and heterologous immunity during postnatal infections. We evaluate the immunity to parasite antigens and ovalbumin (OA) in adult mice born/suckled by schistosomotic mothers. Newborns were divided into born (BIM), suckled (SIM) or born/suckled (BSIM) in schistosomotic mothers, and animals from noninfected mothers (control). When adults, the mice were infected and compared the hepatic granuloma size and cellularity. Some animals were OA + adjuvant immunised. We evaluated hypersensitivity reactions (HR), antibodies levels (IgG1/IgG2a) anti-soluble egg antigen and anti-soluble worm antigen preparation, and anti-OA, cytokine production, and CD4+FoxP3+T-cells by splenocytes. Compared to control group, BIM mice showed a greater quantity of granulomas and collagen deposition, whereas SIM and BSIM presented smaller granulomas. BSIM group exhibited the lowest levels of anti-parasite antibodies. For anti-OA immunity, immediate HR was suppressed in all groups, with greater intensity in SIM mice accompanied of the remarkable level of basal CD4+FoxP3+T-cells. BIM and SIM groups produced less interleukin (IL)-4 and interferon (IFN)-g. In BSIM, there was higher production of IL-10 and IFN-g, but lower levels of IL-4 and CD4+FoxP3+T-cells. Thus, pregnancy in schistosomotic mothers intensified hepatic fibrosis, whereas breastfeeding diminished granulomas in descendants. Separately, pregnancy and breastfeeding could suppress heterologous immunity; however, when combined, the responses could be partially restored in infected descendants.
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Full text: Available Index: LILACS (Americas) Main subject: Schistosomiasis mansoni / Antibodies, Helminth / Granuloma, Foreign-Body / Immunity, Humoral / Liver Diseases, Parasitic / Animals, Suckling Limits: Animals / Pregnancy Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Pernambuco/BR

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Full text: Available Index: LILACS (Americas) Main subject: Schistosomiasis mansoni / Antibodies, Helminth / Granuloma, Foreign-Body / Immunity, Humoral / Liver Diseases, Parasitic / Animals, Suckling Limits: Animals / Pregnancy Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Pernambuco/BR