Enzymatic activation of the carcinogens 2 phenylethylhydrazine and 1,2 dimethylhydrazine to carbon centered radicals
Braz. j. med. biol. res
;
20(6): 865-8, 1987. ilus
Article
in English
| LILACS
| ID: lil-77468
RESUMO
Spin-trapping experiments demonstrate that oxidation of 1,2-dimethylhydrazine and 2-phenylethylgydrazine generates a comparable yield of carbon-centered radicals when catalyzed by horseradish peroxidase-H2O2. Using oxyhemoglobin as the catalyst, 2-phenylethylgydrazine oxidation generates ten times carbon-centered radicals than 1,2-dimethylhidrazine oxidation. This results is in agreement with oxygen consumption studies from which the apparent KM values of 8.0 mM and 72 mM were calculated for the oxyhemoglobin-catalyzed oxidation of 2-phenylethylhydrazine and 1,2-dimethylhydrazine, respectively. These differences in metabolic activation of mono- and disubstituted hydrazines may be of importance regarding the carcinogenic properties of these derivatives
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Index:
LILACS (Americas)
Main subject:
Peroxidases
/
Phenylhydrazines
/
Oxyhemoglobins
/
Chemistry
/
Dimethylhydrazines
/
Horseradish Peroxidase
/
Methylhydrazines
Country/Region as subject:
Asia
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1987
Type:
Article
/
Congress and conference
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