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Novel nonsense mutation in the katA gene of a catalase-negative Staphylococcus aureus strain
Lagos, Jaime; Alarcón, Pedro; Benadof, Dona; Ulloa, Soledad; Fasce, Rodrigo; Tognarelli, Javier; Aguayo, Carolina; Araya, Pamela; Parra, Bárbara; Olivares, Berta; Hormazábal, Juan Carlos; Fernández, Jorge.
  • Lagos, Jaime; Molecular Genetics Subdepartment. CL
  • Alarcón, Pedro; Molecular Genetics Subdepartment. CL
  • Benadof, Dona; Molecular Genetics Subdepartment. CL
  • Ulloa, Soledad; Molecular Genetics Subdepartment. CL
  • Fasce, Rodrigo; Molecular Genetics Subdepartment. CL
  • Tognarelli, Javier; Molecular Genetics Subdepartment. CL
  • Aguayo, Carolina; Molecular Genetics Subdepartment. CL
  • Araya, Pamela; Molecular Genetics Subdepartment. CL
  • Parra, Bárbara; Molecular Genetics Subdepartment. CL
  • Olivares, Berta; Molecular Genetics Subdepartment. CL
  • Hormazábal, Juan Carlos; Molecular Genetics Subdepartment. CL
  • Fernández, Jorge; Molecular Genetics Subdepartment. CL
Braz. j. microbiol ; 47(1): 177-180, Jan.-Mar. 2016. tab
Article in English | LILACS | ID: lil-775102
ABSTRACT
Abstract We report the first description of a rare catalase-negative strain of Staphylococcus aureus in Chile. This new variant was isolated from blood and synovial tissue samples of a pediatric patient. Sequencing analysis revealed that this catalase-negative strain is related to ST10 strain, which has earlier been described in relation to S. aureus carriers. Interestingly, sequence analysis of the catalase gene katA revealed presence of a novel nonsense mutation that causes premature translational truncation of the C-terminus of the enzyme leading to a loss of 222 amino acids. Our study suggests that loss of catalase activity in this rare catalase-negative Chilean strain is due to this novel nonsense mutation in the katA gene, which truncates the enzyme to just 283 amino acids.
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Full text: Available Index: LILACS (Americas) Main subject: Staphylococcal Infections / Staphylococcus aureus / Catalase / Codon, Nonsense Limits: Child, preschool / Humans Country/Region as subject: South America / Chile Language: English Journal: Braz. j. microbiol Journal subject: Microbiology Year: 2016 Type: Article Affiliation country: Chile Institution/Affiliation country: Molecular Genetics Subdepartment/CL

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Full text: Available Index: LILACS (Americas) Main subject: Staphylococcal Infections / Staphylococcus aureus / Catalase / Codon, Nonsense Limits: Child, preschool / Humans Country/Region as subject: South America / Chile Language: English Journal: Braz. j. microbiol Journal subject: Microbiology Year: 2016 Type: Article Affiliation country: Chile Institution/Affiliation country: Molecular Genetics Subdepartment/CL