Novel nonsense mutation in the katA gene of a catalase-negative Staphylococcus aureus strain
Braz. j. microbiol
;
47(1): 177-180, Jan.-Mar. 2016. tab
Article
in English
| LILACS
| ID: lil-775102
ABSTRACT
Abstract We report the first description of a rare catalase-negative strain of Staphylococcus aureus in Chile. This new variant was isolated from blood and synovial tissue samples of a pediatric patient. Sequencing analysis revealed that this catalase-negative strain is related to ST10 strain, which has earlier been described in relation to S. aureus carriers. Interestingly, sequence analysis of the catalase gene katA revealed presence of a novel nonsense mutation that causes premature translational truncation of the C-terminus of the enzyme leading to a loss of 222 amino acids. Our study suggests that loss of catalase activity in this rare catalase-negative Chilean strain is due to this novel nonsense mutation in the katA gene, which truncates the enzyme to just 283 amino acids.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Staphylococcal Infections
/
Staphylococcus aureus
/
Catalase
/
Codon, Nonsense
Limits:
Child, preschool
/
Humans
Country/Region as subject:
South America
/
Chile
Language:
English
Journal:
Braz. j. microbiol
Journal subject:
Microbiology
Year:
2016
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Molecular Genetics Subdepartment/CL
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