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Effect of ozone on colon anastomoses in rat peritonitis model
Çakır, Tuğrul; Aslaner, Arif; Tekeli, Seçkin Özgür; Avcı, Sema; Doğan, Uğur; Tekeli, Feyza; Soylu, Hakan; Akyüz, Cebrail; Koç, Süleyman; Üstünel, İsmail; Yılmaz, Necat.
  • Çakır, Tuğrul; Antalya Training and Research Hospital. Department of General Surgery. Antalya. TR
  • Aslaner, Arif; Antalya Training and Research Hospital. Department of General Surgery. Antalya. TR
  • Tekeli, Seçkin Özgür; Antalya Training and Research Hospital. Department of General Surgery. Antalya. TR
  • Avcı, Sema; Antalya Training and Research Hospital. Department of General Surgery. Antalya. TR
  • Doğan, Uğur; Antalya Training and Research Hospital. Department of General Surgery. Antalya. TR
  • Tekeli, Feyza; Antalya Training and Research Hospital. Department of General Surgery. Antalya. TR
  • Soylu, Hakan; Antalya Training and Research Hospital. Department of General Surgery. Antalya. TR
  • Akyüz, Cebrail; Antalya Training and Research Hospital. Department of General Surgery. Antalya. TR
  • Koç, Süleyman; Antalya Training and Research Hospital. Department of General Surgery. Antalya. TR
  • Üstünel, İsmail; Antalya Training and Research Hospital. Department of General Surgery. Antalya. TR
  • Yılmaz, Necat; Antalya Training and Research Hospital. Department of General Surgery. Antalya. TR
Acta cir. bras ; 31(2): 111-118, Feb. 2016. graf
Article in English | LILACS | ID: lil-775561
ABSTRACT

PURPOSE:

To investigate the effects of medical ozone theraphy on the colon anastomosis of peritonitis model in rats.

METHODS:

Eighteen rats were randomly assigned into three equal groups; control, cecal punctuation and colon anastomosis and ozone theraphy. Sepsis was performed with a cecal punctuation in groups 2 and 3. The medical ozone theraphy was administered intraperitonealy for three weeks in group 3 while the other rats received saline injection. At the twenty second day serum were obtained for TNF-α and IL-1β, the colonic burst pressures were measured and colonic tissue samples were obtained for MDA and MPO levels. Histolopatological examination was evaluated with H&E stain, and Ki-67, IL-1β and the VEGF immunostaining densities were also compared.

RESULTS:

Intraperitoneal ozone administration reversed TNF-α, IL-1β, MDA and MPO levels and the colonic burst pressures. There was also a significant difference at immunostaining densities of histopathological examination.

CONCLUSION:

Medical ozone therapy may contribute to tissue healing by affecting the proliferation and the vascularization thus has benefits on colonic anastomosis at peritonitis in rats.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Ozone / Peritonitis / Wound Healing / Colon Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2016 Type: Article Affiliation country: Turkey Institution/Affiliation country: Antalya Training and Research Hospital/TR

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Full text: Available Index: LILACS (Americas) Main subject: Ozone / Peritonitis / Wound Healing / Colon Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2016 Type: Article Affiliation country: Turkey Institution/Affiliation country: Antalya Training and Research Hospital/TR