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Clostridium difficile outbreak caused by NAP1/BI/027 strain and non-027 strains in a Mexican hospital
Morfin-Otero, Rayo; Garza-Gonzalez, Elvira; Aguirre-Diaz, Sara A.; Escobedo-Sanchez, Rodrigo; Esparza-Ahumada, Sergio; Perez-Gomez, Hector R.; Petersen-Morfin, Santiago; Gonzalez-Diaz, Esteban; Martinez-Melendez, Adrian; Rodriguez-Noriega, Eduardo; Hospital Civil de Guadalajara, Fray Antonio Alcalde Clostridium difficile Team.
  • Morfin-Otero, Rayo; Hospital Civil de Guadalajara. MX
  • Garza-Gonzalez, Elvira; Hospital Civil de Guadalajara. MX
  • Aguirre-Diaz, Sara A.; Hospital Civil de Guadalajara. MX
  • Escobedo-Sanchez, Rodrigo; Hospital Civil de Guadalajara. MX
  • Esparza-Ahumada, Sergio; Hospital Civil de Guadalajara. MX
  • Perez-Gomez, Hector R.; Hospital Civil de Guadalajara. MX
  • Petersen-Morfin, Santiago; Hospital Civil de Guadalajara. MX
  • Gonzalez-Diaz, Esteban; Hospital Civil de Guadalajara. MX
  • Martinez-Melendez, Adrian; Hospital Civil de Guadalajara. MX
  • Rodriguez-Noriega, Eduardo; Hospital Civil de Guadalajara. MX
Braz. j. infect. dis ; 20(1): 8-13, Jan.-Feb. 2016. tab
Article in English | LILACS | ID: lil-776470
ABSTRACT
Abstract Background Clostridium difficile infections caused by the NAP1/B1/027 strain are more severe, difficult to treat, and frequently associated with relapses. Methods A case–control study was designed to examine a C. difficileinfection (CDI) outbreak over a 12-month period in a Mexican hospital. The diagnosis of toxigenic CDI was confirmed by real-time polymerase chain reaction, PCR (Cepheid Xpert C. difficile/Epi). Results During the study period, 288 adult patients were evaluated and 79 (27.4%) patients had confirmed CDI (PCR positive). C. difficilestrain NAP1/B1/027 was identified in 31 (39%) of the patients with confirmed CDI (240 controls were included). Significant risk factors for CDI included any underlying disease (p < 0.001), prior hospitalization (p < 0.001), and antibiotic (p < 0.050) or steroid (p < 0.001) use. Laboratory abnormalities included leukocytosis (p < 0.001) and low serum albumin levels (p < 0.002). Attributable mortality was 5%. Relapses occurred in 10% of patients. Risk factors for C. difficileNAP1/B1/027 strain infections included prior use of quinolones (p < 0.03). Risk factors for CDI caused by non-027 strains included chronic cardiac disease (p < 0.05), chronic renal disease (p < 0.009), and elevated serum creatinine levels (p < 0.003). Deaths and relapses were most frequent in the 027 group (10% and 19%, respectively). Conclusions C. difficile NAP1/BI/027 strain and non-027 strains are established pathogens in our hospital. Accordingly, surveillance ofC. difficile infections is now part of our nosocomial prevention program.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Cross Infection / Disease Outbreaks / Clostridioides difficile / Clostridium Infections Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Aged / Female / Humans / Male Country/Region as subject: Mexico Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2016 Type: Article Affiliation country: Mexico Institution/Affiliation country: Hospital Civil de Guadalajara/MX

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Full text: Available Index: LILACS (Americas) Main subject: Cross Infection / Disease Outbreaks / Clostridioides difficile / Clostridium Infections Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Aged / Female / Humans / Male Country/Region as subject: Mexico Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2016 Type: Article Affiliation country: Mexico Institution/Affiliation country: Hospital Civil de Guadalajara/MX