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Mutations in the S gene and in the overlapping reverse transcriptase region in chronic hepatitis B Chinese patients with coexistence of HBsAg and anti-HBs
Ding, Feng; Miao, Xi-Li; Li, Yan-Xia; Dai, Jin-Fen; Yu, Hong-Gang.
  • Ding, Feng; Renmin Hospital of Wuhan University. Department of Gastroenterology. CN
  • Miao, Xi-Li; Renmin Hospital of Wuhan University. Department of Gastroenterology. CN
  • Li, Yan-Xia; Renmin Hospital of Wuhan University. Department of Gastroenterology. CN
  • Dai, Jin-Fen; Renmin Hospital of Wuhan University. Department of Gastroenterology. CN
  • Yu, Hong-Gang; Renmin Hospital of Wuhan University. Department of Gastroenterology. CN
Braz. j. infect. dis ; 20(1): 1-7, Jan.-Feb. 2016. tab, graf
Article in English | LILACS | ID: lil-776471
Responsible library: BR1.1
ABSTRACT
Abstract Background The mechanism underlying the coexistence of hepatitis B surface antigen and antibodies to HBsAg in chronic hepatitis B patients remains unknown. Aims This research aimed to determine the clinical and virological features of the rare pattern. Methods A total of 32 chronic hepatitis B patients infected by HBV genotype C were included 15 carrying both HBsAg and anti-HBs (group I) and 17 solely positive for HBsAg (group II). S gene and reverse transcriptase region sequences were amplified, sequenced and compared with the reference sequences. Results The amino acid variability within major hydrophilic region, especially the “a” determinant region, and within reverse transcriptase for regions overlapping the major hydrophilic region in group I is significantly higher than those in group II. Mutation sI126S/T within the “a” determinant was the most frequent change, and only patients from group I had the sQ129R, sG130N, sF134I, sG145R amino acid changes, which are known to alter immunogenicity. Conclusions In chronic patients, the concurrent HBsAg/anti-HBs serological profile is associated with an increased aa variability in several key areas of HBV genome. Additional research on these genetic mutants are needed to clarify their biological significance for viral persistence.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Viral Envelope Proteins / Hepatitis B virus / RNA-Directed DNA Polymerase / Hepatitis B, Chronic / Hepatitis B Antibodies / Hepatitis B Surface Antigens Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2016 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Renmin Hospital of Wuhan University/CN

Full text: Available Index: LILACS (Americas) Main subject: Viral Envelope Proteins / Hepatitis B virus / RNA-Directed DNA Polymerase / Hepatitis B, Chronic / Hepatitis B Antibodies / Hepatitis B Surface Antigens Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2016 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Renmin Hospital of Wuhan University/CN