Borage oil attenuates progression of cardiac remodeling in rats after myocardial infarction
Acta cir. bras
;
31(3): 190-197, Mar. 2016. tab, graf
Article
in English
| LILACS
| ID: lil-777097
ABSTRACT
ABSTRACT PURPOSE:
To investigate the effects of Borage oil on cardiac remodeling after myocardial infarction (MI).METHODS:
Male Wistar rats underwent ligation of the left coronary artery and divided into three groups MI (control), BO-18 (18 mg/kg of borage oil) and BO-180 (180 mg/kg of borage oil). After seven days, heart was arrested in diastole and processed for histological evaluation of MI size, LV dilation, myocyte hypertrophy, inflammatory infiltration and fibrosis in MI region and in remote region. The relative weight of the lung was used as a marker of heart failure. The MI size was comparable among groups.RESULTS:
Compared to control, BO treated groups showed lower weight of heart and lungs, reduced LV dilation and myocyte hypertrophy. Hemodynamic measurements were comparable. The treatment attenuated the inflammatory infiltration and fibrosis in remote myocardium.CONCLUSION:
Borage oil attenuates progression of cardiac remodeling after myocardial infarction and congestive heart failure.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Plant Oils
/
Gamma-Linolenic Acid
/
Ventricular Remodeling
/
Heart Ventricles
/
Anti-Inflammatory Agents
/
Myocardial Infarction
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2016
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade da Cidade de São Paulo/BR
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