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Genotoxic potential of 10% and 16% Carbamide Peroxide in dental bleaching
ALMEIDA, Aline Ferreira de; TORRE, Eliana do Nascimento; SELAYARAN, Maicon dos Santos; LEITE, Fábio Renato Manzolli; DEMARCO, Flávio Fernando; LOGUERCIO, Alessandro Dourado; ETGES, Adriana.
  • ALMEIDA, Aline Ferreira de; Universidade Federal de Pelotas. School of Dentistry. Department of Semiology and Clinics. Pelotas. BR
  • TORRE, Eliana do Nascimento; Universidade Federal de Pelotas. School of Dentistry. Department of Semiology and Clinics. Pelotas. BR
  • SELAYARAN, Maicon dos Santos; Universidade Federal de Pelotas. School of Dentistry. Department of Semiology and Clinics. Pelotas. BR
  • LEITE, Fábio Renato Manzolli; Universidade Federal de Pelotas. School of Dentistry. Department of Semiology and Clinics. Pelotas. BR
  • DEMARCO, Flávio Fernando; Universidade Federal de Pelotas. School of Dentistry. Department of Semiology and Clinics. Pelotas. BR
  • LOGUERCIO, Alessandro Dourado; Universidade Federal de Pelotas. School of Dentistry. Department of Semiology and Clinics. Pelotas. BR
  • ETGES, Adriana; Universidade Federal de Pelotas. School of Dentistry. Department of Semiology and Clinics. Pelotas. BR
Braz. oral res. (Online) ; 29(1): 1-7, 2015. tab, ilus
Article in English | LILACS | ID: lil-777227
ABSTRACT
Dental bleaching has become one of the most frequently requested esthetic treatments in dental offices. Despite the high clinical success observed with this procedure, some adverse effects have been reported, including a potential for developing premalignant lesions, root resorption and tooth sensitivity, especially when misused. The aim of this study was to evaluate the genotoxic response using a micronucleus (MN) assay, after the application of two concentrations of carbamide peroxide. Thirty-seven patients were divided into two groups and randomly received either a 10% carbamide peroxide (CP) (19) or a 16% carbamide peroxide (18) concentration for 21 days in individual dental trays. Gingival margin cells were collected immediately before the first use (baseline), and then 15 and 45 days after baseline. The cells were placed on a histological slide, stained by the Feulgen technique, and evaluated by an experienced blinded examiner. One thousand cells per slide were counted, and the MN rate was determined. The two groups were analyzed by the Wilcoxon rank-sum test and the Kruskal-Wallis equality-of-populations rank test. A slight increase in MN was observed for both groups, in comparison with the baseline, at 15 days. However, no difference was observed between the two groups (10% and 16%), at either 15 or 45 days (p = 0.90). When bleaching is not prolonged or not performed very frequently, bleaching agents containing carbamide peroxide alone will not cause mutagenic stress on gingival epithelial cells.
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Full text: Available Index: LILACS (Americas) Main subject: Peroxides / Tooth Bleaching / Urea / Gingiva Type of study: Controlled clinical trial / Evaluation studies Limits: Adult / Female / Humans / Male Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2015 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Pelotas/BR

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Full text: Available Index: LILACS (Americas) Main subject: Peroxides / Tooth Bleaching / Urea / Gingiva Type of study: Controlled clinical trial / Evaluation studies Limits: Adult / Female / Humans / Male Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2015 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Pelotas/BR