Xylazine antinociception in mice: evidence for mediation by postsynaptic adrenoceptors

Naves, L. A; Freire, A. C. T

Naves, L. A; Freire, A. C. T.

Braz. j. med. biol. res ; 22(8): 1009-10, 1989. ilus

Article in English | LILACS | ID: lil-77746

RESUMO

RESUMO

The influence of 6-hydroxydopamine (6-OHDA) pretreatment on zylazine (XLZ)-induced antinociception was studied in mice using the writhing test (60 mg/Kg acetic acid, ip, as the algogenic compound administered 10 min after 0.5 0.75 mg/Kg XLZ, sc). 6-OHDA (100 mgKg-1 injection-1 administered ip on days 1, 3, 5, 7, 9 and 11 after bith) did not modify XLZ- induced antinociception, suggesting that effects is mediated by postsynaptic alpha-2 adrnoceptors

Subject(s)

Mice; Animals; Male; Analgesia; Hydroxydopamines/therapeutic use; Pain Measurement; Xylazine/pharmacology; Dose-Response Relationship, Drug; Receptors, Adrenergic, alpha/metabolism

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Index: LILACS (Americas) Main subject: Xylazine / Pain Measurement / Hydroxydopamines / Analgesia Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 1989 Type: Article / Congress and conference

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