Glycemia and immunohistochemical changes in the endocrine pancreas of the turtle Chrysemys dorbigni treated with streptozotocin
Braz. j. med. biol. res
;
22(8): 1033-7, 1989. ilus, tab
Article
in English
| LILACS
| ID: lil-77752
ABSTRACT
The diabetogenic action of streptozotocin (SZ) was inbestigated in the turtle Chrysemys dorbigni after a 1-or 14-day fast. SZ (130 or 250 mg/Kg) was inected intravenously, and blood glucose and plasma insulin were measured. Pancreatic endocrine cells were stained immunohistochemically by the immunoperoxidase avidin-biotin-peroxidase complex method. Only 14% of the SZ-treated turtles showed hyperglycemia. Prolonged fasting did not increase the percentage of hyperglycemic animals. In control turtles, insulin (ß-, glucagon (alfa)-and somatostatin (delta)-immunoreactive cells were detected in increasing order of frequency. The qualitative changes seen in cells from the hyperglycemic SZ-treated turtles were more evident in ß and delta cells
Search on Google
Index:
LILACS (Americas)
Main subject:
Blood Glucose
/
Islets of Langerhans
/
Streptozocin
/
Insulin
Type of study:
Qualitative research
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1989
Type:
Article
/
Project document
Similar
MEDLINE
...
LILACS
LIS