Expansibilidad del tejido adiposo en la homeostasis metabólica / Expandability of adipose tissue in metabolic homeostasis
Rev. chil. endocrinol. diabetes
;
7(1): 14-16, ene.2014.
Article
in Spanish
| LILACS
| ID: lil-779328
ABSTRACT
The ability to expand adipose tissue mass may prevent ectopic lipid accumulation and insulin resistance in response to energy oversupply and high-fat diet. Indeed, mice fed with a high-fat diet that overexpresses adiponectin (a lipogenic gene) and are leptin-deficient develop massive obesity; however, have better metabolic profile than leptin-deficient control mice. Furthermore, mice with a deletion of PPARg2 gene (an adipogenic transcription factor) have impaired adipogenic capacity and ability to expand fat mass. These animals in response to a high-fat diet are leaner and present severe insulin resistance. In humans, some of the most striking relevance of adipose tissue for metabolic control came from patients suffering of generalized lipodystrophy. On them, there is an inability to develop subcutaneous adipose tissue, which is accompanied by elevated ectopic lipid accumulation and insulin resistance. Based on this and other evidence, the role of adipose tissue as a buffering lipid tissue controlling whole-body glucose and lipid homeostasis has gained relevance. I hereby further expand on this concept and highlight future research...
Full text:
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Index:
LILACS (Americas)
Main subject:
Adipose Tissue
/
Homeostasis
/
Obesity
Limits:
Humans
Language:
Spanish
Journal:
Rev. chil. endocrinol. diabetes
Journal subject:
Endocrinology
Year:
2014
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Pontificia Universidad Católica de Chile/CL
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