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Human leucocyte antigen profile in patients with aids and cytomegalovirus retinitis with and without macular involvement
Souza, Nivaldo Vieira de; Federal University of Santa Catarina; Ribeirão Preto Medical School University Hospital; Donadi, Eduardo Antonio; Rodrigues, Maria de Lourdes Veronese.
  • Souza, Nivaldo Vieira de; University of São Paulo. Otorhinolaringology and Head and Neck Surgery. Department of Ophthalmology. Ribeirão Preto. BR
  • Federal University of Santa Catarina; Faculty of Medicine. Department of Surgery. Souza, Eduardo Soares Maia Vieira de. Florianópolis. BR
  • Ribeirão Preto Medical School University Hospital; Laboratory of Molecular Immunology. Ribeirão Preto. Deghaide, Neifi Hassam Saloum. Ribeirão Preto. BR
  • Donadi, Eduardo Antonio; University of São Paulo. Department of Internal Medicine. Division of Immunology. Ribeirão Preto. BR
  • Rodrigues, Maria de Lourdes Veronese; University of São Paulo. Otorhinolaringology and Head and Neck Surgery. Department of Ophthalmology. Ribeirão Preto. BR
Clin. biomed. res ; 35(1): 14-19, 2015. ilus, tab
Article in English | LILACS | ID: lil-780281
ABSTRACT
Cytomegalovirus retinitis is one of the ocular manifestations of AIDS. The objective of the present study was to determine possible associations of class I and II HLA antigens and alleles in patients with AIDS and cytomegalovirus retinitis (CMV-R) with and without macular involvement.

Method:

The study population consisted of 22 patients with AIDS and CMV-R with macular involvement (Group I), 19 patients with AIDS and CMV-R without macular involvement (Group II), and 202 individuals with negative serology for human immunodeficiency virus (Group III - control). Class I HLA antigens were typed by classical serology. Class II alleles were identified using sequence-specific oligonucleotide primers hybridized with amplified DNA.

Results:

HLA-DRB1*14 and HLA-DRB1*10 specificities were more frequent among patients with macular involvement, possibly indicating greater susceptibility to this condition. In contrast, the HLA-B35 antigen may be associated with protection against macular involvement since it was significantly more frequent among patients without this involvement.

Conclusions:

The HLA-DRB1*14 and HLA-DRB1*10 alleles may favor the development of CMV-R with macular involvement, whereas the HLA-B35 subtype may be associated with protection against macular involvement...
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: AIDS-Related Opportunistic Infections / Cytomegalovirus Retinitis Limits: Humans / Male Language: English Journal: Clin. biomed. res Journal subject: Medicine Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculty of Medicine/BR / Laboratory of Molecular Immunology/BR / University of São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: AIDS-Related Opportunistic Infections / Cytomegalovirus Retinitis Limits: Humans / Male Language: English Journal: Clin. biomed. res Journal subject: Medicine Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculty of Medicine/BR / Laboratory of Molecular Immunology/BR / University of São Paulo/BR