Human leucocyte antigen profile in patients with aids and cytomegalovirus retinitis with and without macular involvement
Clin. biomed. res
;
35(1): 14-19, 2015. ilus, tab
Article
in English
| LILACS
| ID: lil-780281
ABSTRACT
Cytomegalovirus retinitis is one of the ocular manifestations of AIDS. The objective of the present study was to determine possible associations of class I and II HLA antigens and alleles in patients with AIDS and cytomegalovirus retinitis (CMV-R) with and without macular involvement. Method:
The study population consisted of 22 patients with AIDS and CMV-R with macular involvement (Group I), 19 patients with AIDS and CMV-R without macular involvement (Group II), and 202 individuals with negative serology for human immunodeficiency virus (Group III - control). Class I HLA antigens were typed by classical serology. Class II alleles were identified using sequence-specific oligonucleotide primers hybridized with amplified DNA.Results:
HLA-DRB1*14 and HLA-DRB1*10 specificities were more frequent among patients with macular involvement, possibly indicating greater susceptibility to this condition. In contrast, the HLA-B35 antigen may be associated with protection against macular involvement since it was significantly more frequent among patients without this involvement.Conclusions:
The HLA-DRB1*14 and HLA-DRB1*10 alleles may favor the development of CMV-R with macular involvement, whereas the HLA-B35 subtype may be associated with protection against macular involvement...
Full text:
Available
Index:
LILACS (Americas)
Main subject:
AIDS-Related Opportunistic Infections
/
Cytomegalovirus Retinitis
Limits:
Humans
/
Male
Language:
English
Journal:
Clin. biomed. res
Journal subject:
Medicine
Year:
2015
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Faculty of Medicine/BR
/
Laboratory of Molecular Immunology/BR
/
University of São Paulo/BR
Similar
MEDLINE
...
LILACS
LIS