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Effects of polymeric zinc propylen-bis-dithiocarbamate (propineb) on nasal mucosa in rats / Efectos de los polímeros del zinc propileno-bis-ditiocarbamato (propineb) en la mucosa nasal de ratas
Samanci, Baver; Arslan, Eda; Samanci, Seyla Bolukbasi; Caypinar, Basak; Deveci, Engin; Söker, Sevda; Seker, Ugur.
  • Samanci, Baver; Academy of Hospital. Head and Neck Surgery. Department of Otorhinolaryngology. Diyarbakir. TR
  • Arslan, Eda; Education Research Hospital of Ankara. Head and Neck Surgery. Department of Otorhinolaryngology. TR
  • Samanci, Seyla Bolukbasi; Education Research Hospital of Selahaddin Eyyubi. Head and Neck Surgery. Department of Otorhinolaryngology. Diyarbakir. TR
  • Caypinar, Basak; Ersoy Hospital. Head and Neck Surgery. Department of Otorhinolaryngology. Istanbul. TR
  • Deveci, Engin; University of Dicle. School of Medicine. Department of Histology and Embryology. Diyarbakir. TR
  • Söker, Sevda; University of Dicle. School of Medicine. Department of Histology and Embryology. Diyarbakir. TR
  • Seker, Ugur; University of Dicle. School of Medicine. Department of Histology and Embryology. Diyarbakir. TR
Int. j. morphol ; 34(1): 85-89, Mar. 2016. ilus
Article in English | LILACS | ID: lil-780479
ABSTRACT
The objective of this study was to evaluate the histopathologic and immunohistochemical effects of propineb on rat nasal mucosa. Twenty adult Sprague-Dawley rats weighing 180­220 g, were used as experimental animals. The rats were divided into propineb and control groups. The control group received distilled water with spray at the same time period. The experiment was terminated after three weeks. In each case, sections of the nosewere taken. In experimental group, microscopic examination of nasal respiratory mucosa revealed that degenerative changes in epithelium were observed in sections of propineb-treated group. There were also leukocyte infiltration and vascular dilatation detected in the connective tissue.We detected CD34-immunoreactive mononuclear cells and endothel cells in the lamina propria of propineb group. In propineb group compared to the control group, the respiratory epithelium, goblet and basal cell nuclei were stained positive for PCNA. Propineb inhalation may be irritating to the nasal mucosa.
RESUMEN
El objetivo de este estudio fue evaluar los efecto histopatológicos e inmunohistoquímicos del Propineb en la mucosa nasal de 20 ratas Sprague-Dawley adultas con un peso de 180-220 g, las que fueron utilizadas como animales de experimentación. Las ratas se dividieron en grupos Propineb y Control. El grupo control recibió agua destilada en aerosol nasal en el mismo período de tiempo que el grupo Propineb. El experimento duró tres semanas. Posteriormente, en cada caso se tomaron muestras de la mucosa nasal. En el grupo experimental, tratado con Propineb, el examen microscópico de la mucosa respiratoria nasal reveló cambios degenerativos en el epitelio. Se detectó también infiltración de leucocitos y dilatación vascular en el tejido conectivo, junto con células mononucleares CD34 inmunorreactiva y células endoteliales en la lámina propia. En el grupo Propineb, en comparación con el grupo control, los núcleos de la porción respiratoria, las células caliciformes y basales resultaron positivas a la tinción del antígeno nuclear de proliferación celular (PCNA). La inhalación de Propineb puede ser un irritante para la mucosa nasal.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Zineb / Nasal Mucosa Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2016 Type: Article Affiliation country: Turkey Institution/Affiliation country: Academy of Hospital/TR / Education Research Hospital of Ankara/TR / Education Research Hospital of Selahaddin Eyyubi/TR / Ersoy Hospital/TR / University of Dicle/TR

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Full text: Available Index: LILACS (Americas) Main subject: Zineb / Nasal Mucosa Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2016 Type: Article Affiliation country: Turkey Institution/Affiliation country: Academy of Hospital/TR / Education Research Hospital of Ankara/TR / Education Research Hospital of Selahaddin Eyyubi/TR / Ersoy Hospital/TR / University of Dicle/TR