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Sex differences on solid organ histological characteristics after brain death1
Simão, Raif Restivo; Ferreira, Sueli Gomes; Kudo, Guilherme Konishi; Armstrong Junior, Roberto; Silva, Luiz Fernando Ferraz da; Sannomiya, Paulina; Breithaupt-Faloppa, Ana Cristina; Moreira, Luiz Felipe Pinho.
  • Simão, Raif Restivo; Universidade de São Paulo. School of Medicine. BR
  • Ferreira, Sueli Gomes; Universidade de São Paulo. School of Medicine. BR
  • Kudo, Guilherme Konishi; Universidade de São Paulo. School of Medicine. BR
  • Armstrong Junior, Roberto; Universidade de São Paulo. School of Medicine. BR
  • Silva, Luiz Fernando Ferraz da; Universidade de São Paulo. School of Medicine. BR
  • Sannomiya, Paulina; Universidade de São Paulo. School of Medicine. BR
  • Breithaupt-Faloppa, Ana Cristina; Universidade de São Paulo. School of Medicine. BR
  • Moreira, Luiz Felipe Pinho; Universidade de São Paulo. School of Medicine. BR
Acta cir. bras ; 31(4): 278-285, Apr. 2016. tab, graf
Article in English | LILACS | ID: lil-781333
ABSTRACT

PURPOSE:

To investigate gender differences in the evolution of the inflammatory process in rats subjected to brain death (BD).

METHODS:

Adult Wistar rats were divided into three groups female; ovariectomized female; and male rats. BD was induced using intracranial balloon inflation and confirmed by maximal pupil dilatation, apnea, absence of reflex, and drop of mean arterial pressure. Six hours after BD, histological evaluation was performed in lungs, heart, liver and kidneys, and levels of inflammatory proteins, estrogen, progesterone, and corticosterone were determined in plasma.

RESULTS:

In the lungs, females presented more leukocyte infiltration compared to males (p<0.01). Ovariectomized female rat lungs were more hemorrhagic compared to other groups (p<0.001). In the heart, females had higher leukocyte infiltration and tissue edema compared to males (p<0.05). In the liver and kidneys, there were no differences among groups. In female group estradiol and progesterone were sharply reduced 6 hours after BD (p<0.001) to values observed in ovariectomized females and males. Corticosterone levels were similar.

CONCLUSIONS:

Sex hormones influence the development of inflammation and the status of organs. The increased inflammation in lungs and heart of female rats might be associated with the acute reduction in female hormones triggered by BD.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Brain Death / Sex Characteristics / Kidney / Liver / Lung / Myocardium Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Brain Death / Sex Characteristics / Kidney / Liver / Lung / Myocardium Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR