Your browser doesn't support javascript.
loading
Multicenter study for efficacy and safety evaluation of a fixeddose combination gel with adapalen 01% and benzoyl peroxide 2 5% (Epiduo® for the treatment of acne vulgaris in Brazilian population
Sittart, José Alexandre de Souza; Costa, Adilson da; Mulinari-Brenner, Fabiane; Follador, Ivonise; Azulay-Abulafia, Luna; Castro, Lia Cândida Miranda de.
  • Sittart, José Alexandre de Souza; Hospital do Servidor Público Estadual de São Paulo. São Paulo. BR
  • Costa, Adilson da; Hospital do Servidor Público Estadual de São Paulo. São Paulo. BR
  • Mulinari-Brenner, Fabiane; Hospital do Servidor Público Estadual de São Paulo. São Paulo. BR
  • Follador, Ivonise; Hospital do Servidor Público Estadual de São Paulo. São Paulo. BR
  • Azulay-Abulafia, Luna; Hospital do Servidor Público Estadual de São Paulo. São Paulo. BR
  • Castro, Lia Cândida Miranda de; Hospital do Servidor Público Estadual de São Paulo. São Paulo. BR
An. bras. dermatol ; 90(6,supl.1): 1-16, Nov.-Dec. 2015. tab, graf
Article in English | LILACS | ID: lil-781351
ABSTRACT
Abstract

BACKGROUND:

The current options for the treatment of acne vulgaris present many mechanisms of action. For several times, dermatologists try topical agents combinations, looking for better results.

OBJECTIVES:

To evaluate the efficacy, tolerability and safety of a topical, fixed-dose combination of adapalene 0.1% and benzoyl peroxide 2.5% gel for the treatment of acne vulgaris in the Brazilian population.

METHODS:

This is a multicenter, open-label and interventionist study. Patients applied 1.0 g of the fixed-dose combination of adapalene 0.1% and benzoyl peroxide 2.5% gel on the face, once daily at bedtime, during 12 weeks. Lesions were counted in all of the appointments, and the degree of acne severity, overall improvement, tolerability and safety were evaluated in each visit.

RESULTS:

From 79 recruited patients, 73 concluded the study. There was significant, fast and progressive reduction of non-inflammatory, inflammatory and total number of lesions. At the end of the study, 75.3% of patients had a reduction of >50% in non-inflammatory lesions, 69.9% in inflammatory lesions and 78.1% in total number of lesions. Of the 73 patients, 71.2% had good to excellent response and 87.6% had satisfactory to good response. In the first week of treatment, erythema, burning, scaling and dryness of the skin were frequent complaints, but, from second week on, these signals and symptoms have reduced.

CONCLUSION:

The fixed-dose combination of adapalene 0.1% and benzoyl peroxide 2.5% gel is effective, safe, well tolerated and apparently improves patient compliance with the treatment.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Acne Vulgaris / Dermatologic Agents / Adapalene, Benzoyl Peroxide Drug Combination Type of study: Controlled clinical trial / Evaluation studies Limits: Adolescent / Adult / Child Country/Region as subject: South America / Brazil Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital do Servidor Público Estadual de São Paulo/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Acne Vulgaris / Dermatologic Agents / Adapalene, Benzoyl Peroxide Drug Combination Type of study: Controlled clinical trial / Evaluation studies Limits: Adolescent / Adult / Child Country/Region as subject: South America / Brazil Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2015 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital do Servidor Público Estadual de São Paulo/BR