Effect of tranexamic acid on bleeding control in total knee arthroplasty
Acta ortop. bras
;
24(3): 131-136, May-June 2016. tab, Ilus
Article
in English
| LILACS
| ID: lil-782003
ABSTRACT
OBJECTIVES:
To analyze the effectiveness of intravenous (IV) tranexamic acid (TA) in reducing blood loss in total knee arthroplasty (TKA).METHOD:
The population sample was composed of patients with a diagnosis of primary knee osteoarthritis. The patients undergoing TKA were divided in two groups. Group A comprised patients who used IV TA and B group, formed by patients who did not use TA in the intra or post-operative period. For descriptive analysis, quantitative variables were represented by mean and standard deviations when their distribution was normal and interquartile ranges and medians for non-normal variables.RESULTS:
The mean age of patients was 68 years old, most of them were female and with involvement of the left knee. Postoperatively patients who had used IV TA showed less bleeding rate and less hemoglobin rate reduction.CONCLUSION:
The use of IV TA in TKA reduces blood loss in peri- and postoperative periods. Regarding total blood loss reduction, hemoglobin rate and need for blood transfusions, IV TA should be used routinely during TKA since it has been shown to be safe with no increase in side effects as thromboembolic events. Level of Evidence III. Retrospective Comparative Study
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Osteoarthritis
/
Tranexamic Acid
/
Arthroplasty, Replacement, Knee
/
Hemorrhage
/
Knee
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
Acta ortop. bras
Journal subject:
Orthopedics
Year:
2016
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Faculdade de Tecnologia e Ciências de Salvador/BR
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