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Clinical and laboratory characteristics of patients with thyroid diseases with and without alanine aminotransferase levels above the upper tertile – Cross-sectional analytical study
Silva, Nathanael de Oliveira e; Ronsoni, Marcelo Fernando; Colombo, Bruno da Silveira; Corrêa, Carina Gabriela; Hatanaka, Simone Aiko; Canalli, Maria Heloisa Büsi da Silva; Schiavon, Leonardo de Lucca; Narciso-Schiavon, Janaína Luz.
  • Silva, Nathanael de Oliveira e; Universidade Federal de Santa Catarina. Departamento de Medicina Interna. Divisão de Gastroenterologia. Florianópolis. BR
  • Ronsoni, Marcelo Fernando; Universidade Federal de Santa Catarina. Departamento de Medicina Interna. Divisão de Gastroenterologia. Florianópolis. BR
  • Colombo, Bruno da Silveira; Universidade Federal de Santa Catarina. Departamento de Medicina Interna. Divisão de Gastroenterologia. Florianópolis. BR
  • Corrêa, Carina Gabriela; Universidade Federal de Santa Catarina. Departamento de Medicina Interna. Divisão de Gastroenterologia. Florianópolis. BR
  • Hatanaka, Simone Aiko; Universidade Federal de Santa Catarina. Departamento de Medicina Interna. Divisão de Gastroenterologia. Florianópolis. BR
  • Canalli, Maria Heloisa Büsi da Silva; Universidade Federal de Santa Catarina. Departamento de Medicina Interna. Divisão de Gastroenterologia. Florianópolis. BR
  • Schiavon, Leonardo de Lucca; Universidade Federal de Santa Catarina. Departamento de Medicina Interna. Divisão de Gastroenterologia. Florianópolis. BR
  • Narciso-Schiavon, Janaína Luz; Universidade Federal de Santa Catarina. Departamento de Medicina Interna. Divisão de Gastroenterologia. Florianópolis. BR
Arch. endocrinol. metab. (Online) ; 60(2): 101-107, Apr. 2016. tab, graf
Article in English | LILACS | ID: lil-782153
ABSTRACT
Objective Thyroid disease affects 6.6% of the general population. The liver is fundamental in metabolizing thyroid hormones, and hepatocytes are often affected in thyroid disease. We aimed to compare clinical and laboratory parameters among thyroid disease patients with alanine aminotransferase (ALT) levels above vs. below the upper tertile. Subjects and methods A retrospective cross-sectional analytical study was conducted in the endocrinology clinic at Polydoro Ernani de São Thiago University Hospital. Patients with thyroid disease between August 2012 and January 2014 were included in the study. Clinical and laboratory parameters were collected from medical records. Results One hundred patients were included, of which 14.0% were male, with a mean age of 49.1 ± 14.4 years. ALT levels ranged from 9 to 90 U/L, and the ALT upper tertile was defined as 0,64 times the upper normal limit (xUNL). Patients with ALT levels above the upper tertile exhibited a higher proportion of systemic arterial hypertension (SAH), a higher mean abdominal circumference and a higher frequency of elevated TSH levels than did patients with ALT levels below the upper tertile. In multivariate analysis, ALT ≥ 0.64 (xUNL) was independently associated with abdominal circumference (odds ratio [OR] = 0.087, 95% confidence interval [CI] 0012-0167, P = 0.022). ALT (xUNL) correlated positively with total cholesterol (r = 0.213, P = 0.042). Conclusions In patients with thyroid diseases, it was observed that those with ALT above the upper tertile are associated with abdominal circumference and ALT levels correlate with total cholesterol.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Thyroid Diseases / Alanine Transaminase Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Santa Catarina/BR

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Full text: Available Index: LILACS (Americas) Main subject: Thyroid Diseases / Alanine Transaminase Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Santa Catarina/BR